After two years labor in this position, some gentlemen connected with the property on University Heights, requested him to engage in the enterprise of a school on the Heights, in the building erected for a college under president Mahan, but which now lay unfinished and unoccupied, the college scheme having failed. They offered rent and grounds free, but he refused, until they agreed to sell him the whole property for a nominal sum, if he could acquire a clear title, the ownership having become badly involved by the failure of the college. This he eventually accomplished after much labor, and took possession of the property in 1856. The task was a gigantic one to a man like Mr. Humiston, with limited funds and uncertain health. The building was unfinished and needed considerable expenditure to put it in shape for occupation. The location though very promising in the distant future, was then very inconvenient of access, and was therefore objectionable. But Mr. Humiston possessed a determined will and he set to work without delay. He borrowed money, fitted up a portion of the building, and opened the Cleveland Institute with strong hopes for the future, but gloomy prospects in the present. About the middle of the second year the building took fire and a large portion of the interior was destroyed. The school was closed for six months, and with characteristic energy Mr. Humiston went to work to repair damages, enlarging the building, and again involving himself in debt to meet the expense. Success crowned his enterprise. The number of scholars increased rapidly, and again the building had to be enlarged and improved. The institute was continued ten years, and the gross income in its later years ranged from $20,000 to $31,000 per year. During nearly the whole time Mr. Humiston taught himself, and usually five hours out of the six devoted to studies. At the same time he gave medical lectures at the Western Homoeopathic College, and managed all the affairs of the institute, keeping no agent or steward. He purchased and fitted up in the institute a fine chemical and philosophical apparatus, collected a good library and several valuable cabinets of specimens in natural history, geology, and mineralogy. The corps of teachers was large and of superior talents. In 1868, Mr. Humiston, considering that he had earned a respite from his arduous and unremitting labors, accepted an offer from some gentlemen desirous of establishing a Homoeopathic Hospital, and sold his building' with half the adjoining grounds for $35,000. He then accepted the tender of the agency of the American Missionary Association in Great Britain, and early in 1869 left for Europe, having previously visited the South in order to acquaint himself with the condition of the freedmen, whose cause he designed especially to present. After a year or more spent in this work he designs visiting the remainder of Europe, North Africa, and the Holy Land.