From what has been said, it is clearly important to do our best to put the digestive organs, if possible, in a position to perform their functions, and as in the majority of cases the sluggish bowels are loaded with half-digested or undigested food, it is a good general rule, as a preliminary to the administration of quinine, to administer some unirritating laxative, for which purpose nothing can be better than our old friend and bugbear of childhood, castor oil; and the dose should be repeated whenever constipation becomes a symptom in the course of the case. Once the laxative has acted, the sooner quinine is administered the better, and, unless the patient be one of those unfortunately constituted persons who are unable to take it--and there are some few to whom quinine seems as poisonous as it is to the malarial parasite--it should be given in full doses to the extent of 20 or even 30 grains (1 to 2 grammes of metric system) in the twenty-four hours. A dose of 10 grains, followed by others of 5 grains each, will usually be found a convenient plan of administration; but there are cases which do better with smaller doses more frequently administered. The best way to give it is, I think, to stir up the powder in a little milk; and it may be well here to offer a word of caution as to the employment of the drug in the form of tabuloids. For some reason, the drug appears difficult of digestion in this form, for I have repeatedly found fever yield at once to the ordinary powdered form of the drug, after days of fruitless treatment with quinine tabuloids obtained from firms of so high a reputation that the suggestion of the substitution of some less expensive material for quinine is quite untenable. The indiscriminate use, too, of antipyrin, phenacetin, &c., is also to be deprecated. They are all powerful depressants; and though they afford great relief to the aches and weariness of an attack of fever, undoubtedly have no effect whatever in curing the disease, even if they do not, as I have often been inclined to suspect, tend to prolong it. Where the suffering is very acute, an occasional dose may be of use for securing rest, but anything like continuous dosing with medicines of this sort should be carefully avoided. On the other hand, the old-fashioned “fever mixture,” composed of ten or fifteen drops of nitrous ether with a drachm of Minderus’ spirits (_liquor ammoniæ acetatis_), every four hours, in a wineglass of water, is often of great use in favouring perspiration, besides acting as a useful diuretic; and may be recommended as not only affording much relief to the patient’s subjective symptoms, but also of being absolutely safe even in inexperienced hands. Except in the weakness of very prolonged attacks, stimulants should be but sparingly given, but they should not be withheld when the patient is flagging, and obviously falling into what is known as a “typhoid state.”