1. What is the specific cause of hog-cholera? Give and describe the different methods of spreading the disease. 2. What are the symptoms of hog-cholera? 3. Give the preventive and curative treatment of hog-cholera. 4. What is anti-hog-cholera serum? Give the different methods of vaccination and treatment. CHAPTER XXVII TUBERCULOSIS [Illustration: FIG. 88.--Koch's _Bacillus tuberculosis._] Tuberculosis is a contagious an and domestic animals, affecting any the lymphatic glands and lungs, change in the tissues is the formation tubercle or nodule. HISTORY.--Tuberculosis is one of the oldest of known diseases of domestic animals and man. Its contagious character was proven by Villemin in 1865, who by experential infection transmitted tuberculosis from man to animals and from animal to animal. It was in 1882 that Dr. Robert Koch discovered and proved by inoculation experiments that the disease was caused by a specific germ (Fig. 88). Prior to the experiments by Villemin and Koch, the belief was that tuberculosis was due to heredity, unsanitary conditions and inbreeding. Following discovery of the specific germ and conditions favoring its development and spread, numerous scientifically conducted experiments were made. These resulted in practical methods of control and elimination of tuberculosis from herds having this disease. By carefully conducted experiments and other forms of educational work the infectious character of tuberculosis and the economic importance of preventative measures have been demonstrated. The average stockman is well informed regarding the character and economic importance of this disease, but there is no general application of this knowledge, and tuberculosis is increasing in dairy and breeding herds. The slow development of tuberculosis, and the absence of visible symptoms during the early stage of the disease, are responsible for this condition and the extensive infection of dairy and breeding herds. PREVALENCE OF THE DISEASE.--Tuberculosis is very prevalent among cattle and swine in all countries where intensive agriculture is practised. It is a rare disease among cattle of the steppes of eastern Europe and the cattle ranges of the western portion of the United States. In countries where dairying is an important industry, tuberculosis is a common disease of cattle and hogs. The abattoir reports of Europe and the United States show that tuberculosis is on the increase among domestic animals. The Bureau of Animal Industry of the United States Department of Agriculture reports that out of 400,008 cattle tested with tuberculin 9.25 per cent reacted. Melvin states that the annual loss from tuberculosis in the United States is about $23,000,000. In dairy herds in which the disease has existed for several years, it is not uncommon to find from 25 to 75 per cent tubercular.