_The predisposing causes_ are cold, exposure and changes in climate. When the disease appears in a country, it is first present in the large cities, and from there it is scattered to the outlying districts. The _period of incubation_ is usually from four to seven days. _The early symptoms_ of the disease are a high fever, marked depression and partial or entire loss of appetite. The horse usually stands in the stall with the head down and appears sleepy. The visible and respiratory mucous membranes are inflamed, the respirations are quickened and the animal may cough. The eyes are frequently affected, the lids and cornea showing more or less inflammation. The digestive tract may be affected. At the beginning, colicky pains may be present and later constipation and diarrhoea. Symptoms of a serious nervous disturbance are sometimes manifested. The limbs usually become swollen or filled. This disappears as the animal begins to improve. Pregnant mares may abort. The death-rate is low. _The treatment required for the sick animals_ is largely rest, a light diet and a comfortable, clean, well-ventilated stall, free from draughts. Windows in the stall should be darkened. If the stable is cold, the body of the animal should be covered with a blanket and the limbs bandaged. Two ounces of alcohol and one drachm of quinine may be given three or four times daily. Small doses of raw linseed oil may be given if necessary. Horses that are exposed to cold, wet weather or worked after becoming sick, frequently suffer from pneumonia, pericarditis, gastro-enteritis and other diseases. Such complications should be given prompt treatment. It is very advisable to give a protective serum to horses that are shipped or transported long distances, and exposed to the disease in sale or transfer stables. GLANDERS, FARCY.--This is a contagious and infectious disease of solipeds that is characterized by the formation of nodules and ulcers on the skin, nasal mucous membrane and lungs. Although glanders is one of the oldest of animal diseases, it was not until 1868 that its contagious character was demonstrated. The disease is widely distributed. It became more prevalent in the United States after the Civil War. The vigorous control measures practised by the State and Federal health officers have greatly decreased the percentage of animals affected with glanders. At the present time the disease is more often met with in the large cities than in the agricultural sections of the country. [Illustration: FIG. 114.--_Bacillus mallei_.]