Philo the physician stoutly affirmed that the elephantiasis was a disease but lately known; since none of the ancient physicians speak one word of it, though they oftentimes enlarge upon little, frivolous and obscure trifles. And I, to confirm it, cited Athenodorus the philosopher, who in his first book of Epidemical Diseases says, that not only that disease, but also the hydrophobia or water-dread (occasioned by the biting of a mad dog), were first discovered in the time of Asclepiades. At this the whole company were amazed, thinking it very strange that such diseases should begin then, and yet as strange that they should not be taken notice of in so long a time; yet most of them leaned to this last opinion, as being most agreeable to man, not in the least daring to imagine that Nature affected novelties, or would in the body of man, as in a city, create new disturbances and tumults. And Diogenianus added, that even the passions and diseases of the mind go on in the same old road that formerly they did; and yet the viciousness of our inclination is exceedingly prone to variety, and our mind is mistress of itself, and can, if it please, easily change and alter. Yet all her inordinate motions have some sort of order, and the soul hath bounds to her passions, as the sea to her overflowings. And there is no sort of vice now among us which was not practised by the ancients. There are a thousand differences of appetites and various motions of fear; the schemes of grief and pleasure are innumerable. Yet are not they of late or now produced, And none can tell from whence they first arose. (Sophocles, "Antigone," 456.)