Count Ciantar in his "_Malta illustrata_," gives an interesting account of the introduction of the plague at four different periods in that island. The first was in 1592; when, in the month of May, four galleys belonging to the Grand Duke of Tuscany, entered the port to procure pilots for the service. By permission of the Grand Master, Cardinal Verclula, a pilot was obtained, and the vessels steered towards the Egyptian coast. In the vicinity of Alexandria, they captured a galley bound to Constantinople, having on board 150 Turks. On hearing that the plague was raging at Alexandria, they returned to Malta with their prize, which was discovered to be infected, and for the first time the plague was brought into the country. The second plague broke out in 1623, and originated in the house of Paulus Emilius Ramadus, guardian of the port. But the whole of the infected persons having been immediately sent to the Lazaretto, the progress of the disease was checked, and it only carried off forty-five persons. The third plague took place in 1633, and broke out at the Marina gate, where vessels from the Levant usually anchored. The proprietor of a house in that quarter, having had some communication with one of these ships, contracted the disease, and infected his sister, who resided in the country at Casal Zeitun, and shortly after the whole family was attacked, their speedy removal to the Lazaretto, however arrested the disease. The fourth appearance of this malady in Malta, was far more destructive than it had been in the preceding years, even in 1675, and it continued its ravages for seven months. This circumstance has been attributed to a difference of opinion that prevailed among the members of the commissioners appointed to take the necessary steps for checking the progress of the disease. It appears that doubts were entertained as to the nature of the malady, hence the requisite precautions were not enforced; and instead of separating the diseased from the healthy part of the community, with the utmost rigour, prayers were put up, vows and offerings were made, and processions paraded the streets, nor it was not until the Grand Master had sent to France for medical aid, that the scourge was mitigated. On their arrival the first steps adopted by these physicians was to confine the inhabitants to their homes, and to remove the sick to the Lazaret. The ravages of the disease must have been very great, since out of a population of about 60,000, there died in Valetta 4000, in Burgo 1800, Senglen 2000, Burmola 1200, and in the villages upwards of 200.