The natives of Macassar also call this venomous production _ipo_. They have two varieties of the tree, as in Java; the one called _upas antiar_, and the other, much more violent and prompt in its action, _upas tieute_ In the preparation of the poison for use much mystery is observed by the natives, and various ingredients are mixed up with it; but as they are known to be harmless, such as onion and garlic juice, pepper, ginger, galanga, they are most probably employed to deceive the curious who might wish to ascertain the nature of this deadly composition. Mr. Leschenault having brought home a small quantity of this poison, it was tried by Messrs. Delile and Magendie in several experiments, when it was found to act more or less violently, according to the age and size of the individual, or the quantity of the upas. One grain and a half inoculated in a young dog killed it in four minutes, only producing one convulsive fit. In a dog weighing fourteen pounds, half a grain of upas occasioned death at the expiration of one hour and fifty-seven minutes, during which the animal experienced several violent convulsions. A few drops of diluted upas, injected in the chest of a dog, weighing twenty pounds, occasioned a lock-jaw, which destroyed him in a minute and a half. Eight drops injected in the jugular vein of a horse produced immediate tetanus and speedy death. For further information regarding these cruel experiments we must refer to the experimenter's publication. It appears, however, that the power of this venomous substance is so intense that time does not weaken it; for the upas employed in these experiments had been collected and kept for upwards of seven years, when its effects were as prompt as when tried in a recent state. The natives of Java consider sea-salt as the best antidote, but Mr. Delile found it quite inert: various experiments induced him to think that in these cases death is produced by asphyxia; and he considers the means employed to restore suspended animation in persons supposed to have been drowned, as the most likely to save the life of individuals who might be wounded with this substance. The rapidity with which poisonous substances are absorbed in the system is truly terrific, more especially in such as are of a narcotic nature. The latter act by abolishing all nervous energies, but when applied locally their effects are also local, as is shown by the following experiments of Mueller: "I held the nerve of a frog's leg which was separated from the body, in a watery solution of opium for a short time, and that portion of the nerve lost its irritability, i.e. its property of exciting twitchings of the leg when it was irritated; but below the part that the poison had touched the nerve still retained this function."