"My black powder against ye plague, small-pox, purples, all sorts of feavers, Poyson; either by way of prevention or after Infection. In the Moneth of March take Toades, as many as you will, alive; putt them into an Earthen pott, so yt it be halfe full; Cover it with a broad tyle or Iron plate, then overwhelme the pott, so yt ye bottome may be uppermost; putt charcoals round about it and over it and in the open ayre not in an house; sett it on fire and lett it burne out and extinguish of itself; when it is cold take out the toades; and in an Iron morter pound them very well; and searce them; then in a Crucible calcine them; So againe; pound them & searce them again. The first time they will be a brown powder, the next time blacke. Of this you may give a dragme in a Vehiculum or drinke Inwardly in any Infection taken: and let them sweat upon it in their bedds: but let them not cover their heads; especially in the Small-Pox. For prevention half a dragme will suffice." I do not know what meteorological influence was assigned to the month of March; perhaps it was chosen because toads would be uncommonly hard to get in New England during that month. All the medicines in Dr. Stafford's little collection were not, however, so unalluring, and were, on the whole, very healing and respectable. He prescribed nitre, antimony, rhubarb, jalap, and spermaceti, "the sovereignest thing on earth--for an inward bruise;" and he also culled herbs and simples in vast variety. He gave some very good advice regarding the conduct of a physician, the latter clause of which might well be heeded to-day. "Nota bene. No man can with a good Conscience take a fee or Reward before ye partie receive benefit apparent and then he is not to demand anything but what God shall putt it into the heart of the partie to give him. A man is not to neglect that partie to whom he had once administered but to visit him at least once a day & to medle with no more than he can well attend." The account books of other old New England physicians, and other medical books such as "A Treatise of Choice Spagyrical Preparations," show to us that the seventeenth and eighteenth century medicines, though disgusting, were not deadly. We know what medicines were given the colonists on their sea journey hither: "Oil of Cloves, Origanum, Purging Pills, and Ressin of Jalap" for the toothache; a Diaphoretic Bolus for an "Extream Cold;" Spirits of Castor and Oil of Amber for "Histericall Fitts;" "Seaurell Emplaisters for a broken Shin;" and for other afflictions, "Gascons Powder, Liquorish, Carminative Seeds, Syrup of Saffron, Pectoral Syrups and Somniferous Boluses."