The Mexican war, however, cost Mr. Webster far more than the anxiety and disappointment which it brought to him as a public man. His second son, Major Edward Webster, died near the City of Mexico, from disease contracted by exposure on the march. This melancholy news reached Mr. Webster when important matters which demanded his attention were pending in Congress. Measures to continue the war were before the Senate even after they had ratified the peace. These measures Mr. Webster strongly resisted, and he also opposed, in a speech of great power, the acquisition of new territories by conquest, as threatening the very existence of the nation, the principles of the Constitution, and the Constitution itself. The increase of senators, which was, of course, the object of the South in annexing Texas and in the proposed additions from Mexico, he regarded as destroying the balance of the government, and therefore he denounced the plan of acquisition by conquest in the strongest terms. The course about to be adopted, he said, will turn the Constitution into a deformity, into a curse rather than a blessing; it will make a frame of government founded on the grossest inequality, and will imperil the existence of the Union. With this solemn warning he closed his speech, and immediately left Washington for Boston, where his daughter, Mrs. Appleton, was sinking in consumption. She died on April 28th and was buried on May 1st. Three days later, Mr. Webster followed to the grave the body of his son Edward, which had been brought from Mexico. Two such terrible blows, coming so near together, need no comment. They tell their own sad story. One child only remained to him of all who had gathered about his knees in the happy days at Portsmouth and Boston, and his mind turned to thoughts of death as he prepared at Marshfield a final resting-place for himself and those he had loved. Whatever successes or defeats were still in store for him, the heavy cloud of domestic sorrow could never be dispersed in the years that remained, nor could the gaps which had been made be filled or forgotten.