Again, it may be worth while to remark that Brown-Séquard's experiments do not disprove the possibility of its being some one nerve-centre which is concerned in all cases of traumatic epilepsy. And this possibility becomes, I think, a probability in view of Luciani's recent experiments on the dog. These show that the epileptic condition can be produced in this animal by injury to the cortical substance of the hemispheres, and is then transmitted to progeny[68]. These experiments, therefore, are of great interest--first, as showing that traumatic and transmissible epilepsy is not confined to guinea-pigs; and next, as indicating that the pathological state in question is associated with the highest nerve-centres, which may therefore well be affected by injury to the lower centres, or even by section of a large nerve trunk. [68] _Les fonctions du Cerveau_, p. 102. So much, then, with regard to the case of transmitted epilepsy. But now it must be noted that, even if Weismann's suggestion touching microbes were fully adequate to meet this case, it would still leave unaffected those of transmitted protrusion of the eye, drooping of the eyelid, gangrene of the ear, absence of toes, &c. In all these cases the facts, as stated by Brown-Séquard, are plainly unamenable to any explanation which would suppose them due to microbes, or even to any general neurotic condition induced by the operation. They are much too definite, peculiar, and localized. Doubtless it is on this account that the school of Weismann has not seriously attempted to deal with them, but merely recommends their repetition by other physiologists[69]. Certain criticisms, however, have been urged by Weismann against the _interpretation_ of Brown-Séquard's facts as evidence in favour of the transmission of acquired characters. It does not appear to me that these criticisms present much weight; but it is only fair that we should here briefly consider them[70]. [69] _Essays_, vol. i. p. 82. [70] As Weismann gives an excellent abstract of all the alleged facts up to date (_Essays_, vol. i. pp. 319-324), it is needless for me to supply another, further than that which I have already made from Brown-Séquard.