From purely morphological investigations, Turpin and Schwann, as we have seen, arrived at the notion of the fundamental unity of structure of living beings. And, before long, the researches of chemists gradually led up to the conception of the fundamental unity of their composition. So far back as 1803, Thénard pointed out, in most distinct terms, the important fact that yeast contains a nitrogenous "animal" substance; and that such a substance is contained in all ferments. Before him, Fabroni and Fourcroy speak of the "vegeto-animal" matter of yeast. In 1844 Mulder endeavoured to demonstrate that a peculiar substance, which he called "protein," was essentially characteristic of living matter. In 1846, Payen writes:-- "Enfin, une loi sans exception me semble apparaître dans les faits nombreux que j'ai observés et conduire à envisager sous un nouveau jour la vie végétale; si je ne m'abuse, tout ce que dans les tissus végétaux la vue directe où amplifiée nous permet de discerner sous la forme de cellules et de vaisseaux, ne représente autre chose que les enveloppes protectrices, les réservoirs et les conduits, à l'aide desquels les corps animés qui les secrètent et les façonnent, se logent, puisent et charrient leurs aliments, déposent et isolent les matières excrétées." And again:-- "Afin de compléter aujourd'hui l'énoncé du fait général, je rappellerai que les corps, doué des fonctions accomplies dans les tissus des plantes, sont formés des éléments qui constituent, en proportion peu variable, les organismes animaux; qu'ainsi l'on est conduit à reconnaître une immense unité de composition élémentaire dans tous les corps vivants de la nature."[7] [Footnote 7: Mém. sur les Développements des Végétaux, &c.--_Mém. Présentées_. ix. 1846.] In the year (1846) in which these remarkable passages were published, the eminent German botanist, Von Mohl invented the word "protoplasm," as a name for one portion of those nitrogenous contents of the cells of living plants, the close chemical resemblance of which to the essential constituents of living animals is so strongly indicated by Payen. And through the twenty-five years that have passed, since the matter of life was first called protoplasm, a host of investigators, among whom Cohn, Max Schulze, and Kühne must be named as leaders, have accumulated evidence, morphological, physiological, and chemical, in favour of that "immense unité de composition élémentaire dans tous les corps vivants de la nature," into which Payen had, so early, a clear insight. As far back as 1850, Cohn wrote, apparently without any knowledge of what Payen had said before him:--