Disease and Its CausesCouncilman, W. T. (William Thomas)
Science
Disease and Its Causes
Councilman, W. T. (William Thomas)
Diseases -- Causes and theories of causation
From the lungs the bacilli are carried by the lymphatics to the lymph
nodes at the root of the lungs, in which a similar process takes
place; this, on the whole, is favorable, because further extension by
this route is for a time blocked. The extension by means of surfaces
continues, the abundant sputum which is formed in the lungs and which
contains large numbers of bacilli, becomes the vehicle of
transportation. The windpipe and larynx may become infected, the back
parts of each are more closely in contact with the sputum and are the
parts most generally infected. A large part of the sputum is swallowed
and infection of the intestine takes place, the lesions taking the
form of large ulcers. From the intestinal ulcers there is further
extension by means of the lymphatics, to the large lymph nodes in the
back of the abdominal cavity (Fig. 8-25); the bacilli may also pass
from the ulcers into the abdominal cavity and be distributed over the
surface of the peritoneum resulting in tuberculous peritonitis. When
the disease has reached an advanced stage, bacilli in small numbers
continually pass into the blood and are distributed by this over the
body, producing small nodules in many places. In rare cases
distribution by the blood is the principal method of extension, and
immense numbers of small foci of disease are produced, the form of
disease being known as acute miliary tuberculosis. Although the
bacilli are distributed everywhere, certain organs, as the brain and
muscles, are usually exempt, because in these the conditions are not
favorable to further growth of the bacilli. Tuberculosis, although
frequently a very acute disease, is usually one of the best types of a
chronic disease and may last for many years. The chronic form is
characterized by periods of slow or rapid advance when conditions
arise in the body favorable for the growth of the bacilli, and periods
when the disease is checked and quiescent, the defensive forces of the
body having gained the upper hand. Often the intervention of some
other disease so weakens the defences of the body that the bacilli
again find their opportunity. Thus typhoid fever, scarlet fever and
other diseases may be followed by a rapidly fatal advance of the
tuberculosis, starting from some old and quiescent focus of the
disease.
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