Toxic nephritis is a term applied when the kidney is the seat of epithelial degeneration, much congestion, perhaps leading to tiny hemorrhages, and definite swelling of the tuft without exudation into the capsular space. It is a severe grade of the degenerations already mentioned and is exemplified by the organ in cases of acute duodenitis of ungulates and in some monkeys dying after tuberculin injection. It seems especially to follow gastrointestinal diseases believed to be due to food intoxications. It seems important in monkeys and wild rodents. No adequate explanation is at hand for the latter. As has already been stated vascular disease was present in twenty-six cases in a manner suggesting some relation to the cardiorenal complex but the only organ to which the term renal sclerosis of arteriosclerotic origin could be applied is that of an eagle; the autopsy is cited. Bald Eagle (_Haliæetus leucocephalus_). ♀ General obliterating endoarteritis. Chronic interstitial nephritis. Passive congestion of liver. Chronic localized myocarditis. Near the apex of the heart the muscle shows a slight opacity. The kidney is enlarged, firm, section surface glistening. Both section and surface show a mottled brown and white appearance, following particularly on section the division into cortices and medullæ. Digestive system apparently normal. Microscopic section of heart muscle from the wall of the ventricle shows well preserved muscle fibres with a slightly unusual degree of pigmentation. Section from valve base shows a definite interfascicular and intrafascicular fibrosis which is co-extensive with a similar thickening of the endo- and pericardium. The new tissue under the latter is edematous. The valve itself is thickened the fibres swollen and hyaline. There is no reduplication of the endothelium. One artery in the muscle is obliterated. This is not associated with any degeneration of the muscle in the section. Section of kidney shows the pale areas noted grossly to be made up of groups of arteries with their extensive coalescing adventitiæ. The changes in the arteries are precisely the same as those seen in the liver but are more extensive. Connective tissue goes out from the arteries into the parenchyma distorting the tubules and enclosing the glomeruli so that the capsule of the latter is much thickened. Epithelium is granular, in some places absent, nearly always low. Section of liver shows general parenchyma practically normal with slight granularity in places and moderate passive congestion. Veins are negative but arteries show a general arteritis. The picture varies somewhat in different arteries ranging from a simple thickening of the adventitia to a change involving all three layers. There is hyaline change in the media in many sections. Lumen is in all cases reduced and in some there is active intimal proliferation in excess of what would be expected in