There is little to be learned from the nature and anatomy of the hypertrophies and dilatations except perhaps their character among the birds, in which the physics of the circulation is somewhat peculiar. In this class both the hypertrophy and distention are predominatingly left- sided, a state probably explained by the pressure against which the pump must work in flight because then the lungs and the viscera are somewhat compressed by the pressure of an excess of air in the pneumatic sacs. At all events while concentric hypertrophy was mentioned once, it is difficult to estimate the degree of increase in the right chambers because they are not uncommonly well filled when diastole occurs at death. Grober[10] asserts that the normally large heart (or what I have called “physiological hyperplasia”) shows a “hypertrophy” of the right ventricle because of the extra work entailed in flying. This is certainly not the case in the material we have seen under pathological conditions. Right sided increase might be expected if pulmonary or serous membrane affections were prominent, but left-sided increase, following arteriosclerosis and nephritis is the actual finding. The best examples of concentric hypertrophy are in the dogs with thyroid disease and the best examples of concentric dilatation in ungulates suffering shock. SUMMARY. The foregoing pathological data can now be summarized by grouping the facts under the headings of absolute and relative vulnerability of the heart. By the former is meant the actual number and quality of lesions in the various orders, but here at once one comes upon the irregularity of examples of zoological and pathological character, and if one trust entirely to the percentages, fallacious conclusions might be reached. Basing judgment upon the incidence of pathological lesions in mammals and birds, it is evident that the former has greater vulnerability, as 13 is to 6.2. This is noteworthy as we shall learn that the bird has a larger and apparently better prepared heart than the mammal. Attempts to discover the order or kind of animal having the greatest or lowest vulnerability are difficult for the reason given above. Thus, for instance, Pinnipedia, Proboscidea, Edentata, Gaviæ, Impennes, Steganopodes, and Struthiones present the highest percentages of cardiac lesions, but the total specimens examined are so few that these figures may well be misleading. (See Tables 1 and 2.) If, however, figures mean anything in such small groups, these are the animals which have the greatest cardiac vulnerability. They have little in common in regard to zoological relationships and habits; four of the seven orders are rather slothful and three are active. It is much better to limit our observations to those orders from which sufficient examples have been subjected to autopsy and upon which we have some standards for comparison in the heart-body weight ratio. It so happens that in the