=The prognosis= is grave, unless treatment is early undertaken. In the latter case there is a good chance of recovery. =Lesions.= The macroscopic lesions are not of much interest, being confined to congestion of the intestinal mucous membrane, superficial desquamation of the epithelium, small vascular erosions, and general wasting. The mesenteric lymphatic glands are swollen and œdematous. After death from general infection, it is not uncommon to find pleural, peritoneal, and pericardial exudation or even endocarditis. Even in cases where no post-mortem change has had time to occur cultures from the blood yield varieties of the bacterium _Coli communis_. =Treatment.= The meals should be given at fixed hours, and regulated both as regards quantity and quality. These precautions alone suffice to prevent the appearance of diarrhœic enteritis. Curative treatment has every chance of succeeding when undertaken at the outset. Delafond and Trasbot recommend mild purgatives, which act more rapidly than intestinal antiseptics. These comprise borotartrate of potash in doses of 4 to 5 drachms, sodium sulphate in doses of 2½ to 4 drachms, sulphate of magnesia, etc. By evacuating the bowel and removing a large number of the germs which have multiplied there, they arrest intoxication and prevent infection. Nevertheless, they should not be administered for long, and after one or two doses should be followed by antiseptics like benzo-naphthol, in doses of 15 to 30 grains, salicylic acid in doses of 5 to 10 grains, or salicylate of soda 45 to 60 grains. Mucilaginous and sweetened drinks containing lactic acid in doses of 45 to 75 grains per day may be given between the meals, or at intervals if the calf is sucking. Laudanum in doses of 6 to 10 drops per day administered in rice water, extract of opium, weak solutions of tannin, etc., are also of value. Filliàtre has successfully used tar water in the first stages. The solution consists of vegetable tar 6 drachms, boiling water 1 quart. This solution is used tepid in the proportion of 1 part to 3 parts of warm milk. Decoctions of spiked purple loosestrife, willow bark, etc., are also of great value in certain districts. The drug which appears least dangerous, however, is that so often successfully used in young children—viz., subnitrate of bismuth. It can be given in doses of 30 to 45 grains per day, with lactic acid in doses of 75 to 150 grains, according to the size of the patients. If the animals are greatly exhausted and have been ill for some time there is less chance of recovery, and under these circumstances Dr. Lesage’s anti-colic serum might be used. It gives excellent results in infants, and it has proved successful in simple diarrhœa of calves. CHAPTER VII. POISONING.