The symptoms are those of slight gastro-enteritis without tympanites; but this condition is succeeded by serous, fœtid, uncontrollable diarrhœa, which weakens the animal and causes death from excessive wasting and hydræmia. The sensitiveness of the entire right side of the abdomen, the special diarrhœa, the cardiac disturbance, and the widely distributed œdema, usually suffice to prevent confusion with the ordinary forms of gastro-enteritis. In sheep the diarrhœa is blackish, sometimes blood-stained, and is accompanied by a sub-icteric or icteric tint of the mucous membranes, of the skin, and of all the tissues. The intensity of coloration affords a guide to the rapidity of development of the disease. The urine is also bile-stained, and there appears to be an exchange of functions between the two great depurative organs, the liver and kidney. The urine may become sanguinolent, because it contains either unchanged blood or simply dissolved hæmoglobin. =The lesions= are similar to those previously described, but with modifications of intensity. When diarrhœa has been marked and persistent, the digestive mucous membrane is hardened, indurated, and appears as though tanned. This is due to chronic inflammation, probably to the gastro-enteritis with which the condition begins. The liver appears as if cooked; the fat, the majority of the tissues, and especially the conjunctiva, exhibit a light yellow tint, pointing to hepatic disturbance. =The diagnosis= is generally easy in all three forms, provided that the food be examined. =The prognosis= varies; the acute and nervous forms are usually fatal. But when the disease develops slowly, recovery may occur. =Pathogeny.= Practical observation and laboratory researches show that the above conditions result from poisoning. Histological examination of livers from sheep which have died rapidly shows complete degeneration of the hepatic cells, which become incapable of performing their function. The biliary acids, no longer being withdrawn from the circulating blood, produce general intoxication, destruction of the blood corpuscles, and the appearance of hæmaphæic icterus and hæmoglobinuria.