Certain joints, often a pair, appear swollen, hot and painful. The synovial sacs are distended, and in the upper joints of the limb appear much more prominent than in the lower. When the patients are still able to move they walk on three legs, but usually they remain lying permanently, and if aroused show great difficulty in rising and very acute pain in moving. [Illustration: $1] [Illustration: $1] General disturbance is also very marked; the temperature varies between 103° and 105° Fahr. The animals are dull, have no appetite, and exhibit intense thirst. The pulse rate and respirations are increased, and not uncommonly symptoms of grave visceral complications, such as endocarditis, pleurisy, pneumonia, etc., can be detected. Diarrhœic enteritis sometimes appears as a secondary development. The animals remain permanently lying down. They can only be induced to rise with difficulty, and, when moved, exhibit very acute pain. In many cases the disease then takes a rapid course and ends fatally. Death is the usual termination whenever any of the above-mentioned visceral complications exist. Recovery is exceptional. In certain lucky cases, sometimes without any treatment whatever, the symptoms become less acute, the appetite persists or improves, fever diminishes, the condition of the joints remains stationary, and after the lapse of several weeks there is ground for anticipating recovery. In all cases, however, the convalescents remain thin and sickly, exhibit pain and capricious appetite, and in very few cases indeed is there any economic reason for keeping them alive. More frequently infectious rheumatism terminates by abscess formation in the joints. The articular cavity becomes filled with pus, the tissues covering one of the synovial sacs soften, and the abscess opens, discharging fibrinous clots, thin watery pus mixed with synovia, and _débris_ of articular cartilages or ligaments. Pyæmia is the final complication when the patients are not slaughtered. In the cases comprised under the second heading the symptoms appear more slowly and develop insidiously, the chief, viz., a tendency to remain lying and difficulty in movement, long preceding the appearance of exudative arthritis. The course depends chiefly on the nature of the infective agent. In calves suffering from peripneumonia, calves from stables in which epizootic abortion rages, rachitic calves or calves suffering from severe diarrhœic enteritis, the joints do not become the seat of suppuration. In such cases the arthritis is of a simple exudative character, but without microbic infection of the joint cavity. This form is less dangerous, and is often curable provided the original cause be kept in mind. =Lesions.= The lesions are always very marked, and are quite different from those of simple rheumatism. The synovial membranes and the periarticular tissues are always thickened, injected, inflamed, and infiltrated.