“During the whole course of the disease, his pulse was rapid, but his tongue was remarkably soft and florid. He was never delirious. Latterly, he spit blood once or twice; his lower extremities became very œdematous, and his back was covered with eschars; but these dropped off, and the sores suppurated and healed kindly. Two months before his death, his pains abated considerably. He died without pain, March 4 1784, which was about two years and nine months from the time the seton was passed, and a year and four months from the time he underwent the amputation. “His body was opened a few hours after his death. The abdominal viscera appeared to be perfectly sound, and of their natural colour, except the liver, which had a small steatoma on its convex surface, but was in other respects healthy. The gall bladder was rather fuller of yellow bile than it is generally found to be. The left kidney was enlarged, and on dividing it longitudinally, much red gravel was found in its pelvis, and the ureter seemed much lessened. The urinary bladder was contracted, and its coats uncommonly thickened, but no sabulous concretions were observed in it. “On each side of the vertebræ lumborum, the lumbar regions were rendered convex by a large cancerous deposition, which elevated the psoæ muscles; and when the cellular investitures, which were condensed into a cyst, were opened, the cancerous matter appeared in a large quantity, in colour and consistence exactly resembling the fungus of the hand, and not unlike the substance of the brain. The whole weighed about five pounds; and when this was removed, the last vertebra of the back, and the three first of the loins, were found to be in a softened, eroded, and in some parts a totally dissolved state. There appeared not the least mark of ichor, sanies, inflammation, or hardness of the soft parts; nor were the mesenteric glands at all affected. The matter seemed to have been really a cancerous exudation, and to be formed chiefly of coagulable lymph. This cancerous mass seemed to possess a remarkable dissolving power, which was exerted wholly on the bones, and did not, as usual in cases of this sort, cause any schirrous hardness of the surrounding soft parts.” CASE V. A woman, some time after receiving a blow on the leg, perceived a small moveable tumor. It was soft, elastic, and seated on the outside of the leg, about half way betwixt the knee and ankle joint. I made a small incision through the skin down to the tumor, and dissected it off to its base. I then dissected the substance off from the facia of the muscle, and brought the skin together with adhesive plaster. It united readily, and the patient was cured. The tumor was soft, like brain, of a greyish colour, and greasy consistence. DISSERTATION V. _On the Scrophulous Inflammation._