Various modifications of this treatment have been suggested, such as skimmed milk, and more in quantity, or a cereal is added more or less from the beginning, and perhaps cream. The diuretic action of this treatment is not always successful. Also, sometimes the treatment is even dangerous, the heart and circulation becoming weaker than before such treatment was begun. Certainly the treatment should be used in cardiac insufficiency with a great deal of care, although it is often very valuable treatment. It should be emphasized that most patients with cardiac dropsy receiving the Karell treatment or a modification of it should also receive digitalis in full doses, and should have daily free movement of the bowels. It should be urged, however, that too free catharsis in cardiac weakness is to be avoided, and the prolonged use of salines, and sometimes even one administration is contraindicated. Before cardiac failure has occurred in this disease, once a week a dose of calomel or a brisk saline purge is advisable, and is good treatment; but when cardiac weakness has developed, free catharsis is rarely indicated, although the bowels should be daily moved, and vegetable laxatives are the best treatment. The upper intestine and the liver and kidneys may be relieved by a more or less abrupt modification of the diet, or even a starvation period, and the bowels will generally become cleaned; but frequent profuse purging with salines or some drastic cathartic puts the final touch on a cardiac failure. Recently Goodman [Footnote: Goodman, E. H.: The Use of the "Karell Cure" in the Treatment of Cardiac, Renal and Hepatic Dropsies, Arch. Int. Med., June, 1916, p. 809.] presented a report of his studies of the Karell treatment in cardiac, renal and hepatic dropsies. He finds that patients with uremia ordinarily should not be subjected to the Karell cure, such patients needing more fluid. As long as the patient remains in bed, and as long as his ability to exercise is at a minimum, gentle massage is advisable. In these cases of cardiac weakness, with or without dropsy, unless the diastolic pressure is very high, digitalis is valuable. If there is no cardiac dropsy, but other symptoms of heart tire are manifest and the blood pressure is high, the nitrites are valuable. The amount should be sufficient to lower the blood pressure. Sometimes the diastolic pressure is high and the systolic low and the pressure pulse small because of heart insufficiency; such a condition is often improved by digitalis. In other words, with a failing heart digitalis may not make a blood pressure higher, and often does not; it may even lower a diastolic pressure, and the moment that the pressure pulse becomes sufficient, the patient improves. Under this treatment of digitalis, rest and regulated diet, a dilated left ventricle with a systolic mitral blow often becomes contracted and this regurgitation disappears.