FEVER: Febrile heat, pale face, cold hands. Heat all over. Dry heat all over. 120. Shuddering all over. Cold feeling in the bones. Profuse cold sweat and chilliness, first part of the night. CUTANEOUS: Violet-colored spots on the right hypochondrium. Two yellow spots on the neck. GENERAL: 125. Heaviness and numbness of the extremities. Weakness every morning. The body feels insensible when lying down, as if in a swoon. Prostration. Dartings through the whole body, followed, by itching and violet-colored spots on the arm, back and feet. 130. Numbness of the arms and legs. Contusive pain in the arms and legs. Heaviness of the limbs. JANIPHA MANIHOT. (KUNTH.) JAN. JATROPHA MANIHOT. (LIN.) MANIHOT UTILISSIMA. (POHL.) MANIOCA MANDI. [Illustration] The manioca which is cultivated, a good deal in South-America, for its nutritious root, is a bush with a round and ramose stem, often growing to the size of three feet high. Its leaves, which are of a sea-green color, and supported by long petioles, are alternate, palmate, with five to seven lanciolate, smooth and entire lobes. The flowers, which are monoïchous, form branching panicles either terminal or axillary; their perianth is calicoïd, campanulate, with five deep divisions of a light-yellow color, changing to a brown at the extremity of the divisions. Flowers male, ten stamens, with alternately long and short filaments inserted in a fleshy disk, which, in the female flowers, surrounds the base of a sub-globular ovary, with three uni-ovulate chambers; no style, but three stygmata presenting six or seven thick, compressed lobes that constitute a thick and sinuous mass. The roots, which are tuberculous and very big, contain an abundance of milky juice which is very poisonous when fresh, and which is extracted first by pressure and afterwards by the desiccation of the feculent portion that constitutes the chief nutriment of the Brazilian farmer. It is this juice that we employ in medicine. On the second of July, 1845, a large quantity of this dangerous liquid was expressed before the institute, and an ounce of it was taken by Dr. Jo. Vincente Martins, and several pupils among whom Messrs. Antonio de Souza, Dias and Chedifer, seemed to be the most eager. The symptoms were so violent that most of the provers were obliged to antidote them. We trust that the devotedness of the Brazilian physicians will excite a corresponding enthusiasm among their brethren in other parts. _First day._—1. Eructations, at half past 6 in the morning. Slight feeling of dryness in the œsophagus. Slight weight in the stomach. Drowsy in the day-time. 5. Thirst. Falls asleep late. Stool easier than common. Pain at the velum palati. Pain in the orbits. 10. Pain in the chest. Weakness of the knees in going up-stairs. Sad. Feeble. Dizzy. 15. Acute pain in the left arm, at night.