Several varieties of the caroba are used in Brazil for the treatment of syphilitic diseases. For our provings we have selected the Jacaranda caroba, which has furnished results as complete as could be desired. We consider this drug of great importance in the treatment of chancres. _First day._—1. Stitch at the heart; the heart seems to beat slowly in placing the hand upon it, at 9 in the evening. Stitch and pulling below the stomach, on the right side, at midnight. Dryness and pricking all over. _Second day._—No sleep at night and drowsy in the day-time. 5. Dry mouth, in the morning, in bed. One does not feel any longer the beats of the heart, in the morning, in bed. The heart beats regularly again after going into the open air. Painful stitch at the heart, almost constantly. Full and slow pulse, in the morning, in bed. Weary while talking. 10. Drawing pain on the right side, from the axilla to the false ribs, at 9 in the morning. Dull pain under the sternum, in raising the head and drawing breath. He eats little, though his appetite is good, at 9 in the morning. General weakness, in the morning. Slight pain at the articulation of the second phalanx of the fingers of the right hand, at half past 9 in the morning. 15. Weakness of the legs. Pain as if bruised in the right knee, while walking, at 10 in the morning, of short duration. Sense as if bruised in the muscles and bones of the legs. Slight drawing pain from the eye to the right lower jaw, followed by shuddering in the same region, at 11 in the morning; this pain recurs, changing to a contusive pain. Sensitiveness of the malar bone when pressing on it with the finger. 20. Sensation of painfulness at the apex of the heart, on the right side, at noon. Hurried breathing, with sense of fullness under the sternum, several times in the course of the day. Painful stitch under the false right ribs, at noon. No stool. Momentary drawing in the flexor communis digitorum, left wrist, at half past 12, afternoon. 25. Pulling from the lower extremity of the forearm to the right little finger, for one hour. Weariness of the limbs, and desire to remain seated. Weakness of the limbs; and lumbar region, at 2. Slight pain in the right ribs, below, at half past 2. Painful fullness in the right temple, shifting a moment after to the left temple, and disappearing in the left side of the nape of the neck, in the evening, in the open air. 30. Sense of fullness in the head, in the afternoon. Dull pain between the forehead and right temple; it disappears in the evening, by shifting to the opposite side. Pain as if excoriated at the left side of the tongue. Pulling from the lower jaw to the middle of the neck, on the right side, in the evening. Fullness in the pit of the stomach, with feeble, hurried breathing; sometimes a strong and long inspiration, with strong and sudden expiration, in the afternoon. 35. Lancinating pain in the region of the heart. Continued prickings under the sternum.