Mariano José Machado, fifty years old, of athletic form, bilious-sanguine temperament, was afflicted with elephantiasis leontina Alibert. The whole body, especially the extremities, were insensible. The skin and the cellular tissue were thickened, hard, rugose and covered with tubercles which were somewhat raised but not ulcerated. A few pustules under the arms, looked like itch-pustules, and seemed to indicate a complication with this disease. The epidermis and nails began to alter, and the fingers had lost their normal shape. Internally, the patient felt quite well, enjoying both vigor of mind and body. After six years of suffering, he had come to the determination to try this dreadful experiment, which would either lead to death or a deliverance from his horrible affliction. On the morning of the fourth of September, at fifty minutes past eleven o’clock, he was bit by a rattle-snake, the crotalus cascavella, in the two last fingers near the metacarpus. He felt neither the bite, nor the poison as it penetrated into the wound. A few drops of blood came out of the wound, and the hand began immediately to swell.—In five minutes: slight feeling of coldness in the hands.—Twelve o’clock: slight pain in the hollow of the hands.—Twenty minutes: the hand swells a good deal.—Thirty minutes: swelling of the jugular veins. Alteration of the features. Formication in the face.—Fifty-five minutes: the sense of swelling extends through the whole forearm.—Twenty minutes past one: trembling of the whole body.—Thirty-six minutes past one: the head is affected, with frequent pulse, difficulty of moving the lips, disposition to slumber, constriction of the throat, violent pain in the whole arm, the hand swells more and more.—Thirty-eight minutes past one: sense of chilliness; the patient covers himself.—Forty-eight minutes past one: pain in the tongue and larynx, increased pains and swelling of the bitten hand; sense of coldness in the feet.—Twenty-five minutes past two: difficulty of swallowing,—anguish,—copious sweat on the chest.—Fifty minutes: weakness of the arms,—nosebleed,—anguish, now and then,—restlessness,—pulse 96.—In three hours and forty minutes: pulse 100.—Fifteen minutes: intensely violent pains in the arms.—restlessness.—Thirty minutes: pulse 98,—red face,—continual bleeding of the nose.—Thirty-five minutes: the patient drinks some wine and water without any difficulty, and changes his linen which was all wet from the perspiration.—Intense redness all over.—In four hours: pulse 100,—the whole of the skin, especially on the bitten arm, is very red,—violent pains in both arms, which do not leave the patient any rest,—constriction of the throat,—impeded respiration.—Fifty minutes: pulse 104,—the body is very hot all over,—flow of saliva.—In five hours, thirty minutes: torpor,—copious emission of urine,—thick, viscid saliva, which it is difficult to get out of the mouth,—muscular debility,—frequent moaning on account of the pains which he feels