Weakness of the legs and arms. Sense of weariness as if strained, on waking. Weakness of the extremities. 450. Emaciation. Paleness, cold hands and feet, with weakness during the pains. Fainting spell, with spasms, cramps in the calves and toes. LEPIDIUM BONARIENSE (D. C.). LEP. MASTRUCO. [Illustration] This plant is very common in the neighborhood of Rio, where it is found along the roads and in stony regions. It is herbaceous, with numerous glabrous, erect stems, attaining a height of from twenty to thirty inches; the radical leaves are petiolate, finely indented; the superior leaves are alternate, sessile and almost linear. It blossoms in September. The flowers, which form terminal spikes, are supported by filiform pedicles; calix with four folioles; corol small, cruciform, with four hypozynous petals, six tetradynamous stamens, short style, small, subelliptical pod, which is somewhat crenated at the top; root fibrous, simple, erect. The fresh leaves are triturated. In Brazil the Lepidium bonariense is used for similar purposes as the Arnica. It is universally used in domestic practice. The pathogenesis of this plant may be perhaps welcome to our profession. _First day._—1. Sleeps well until midnight; no sleep since then; has pains all over when stirring. Heat all over, with dull pain; she had the most pain on the left side. Violent pain in the left arm before rising; she cannot stretch it; the more she covers it, the greater is the pain; the pain ceases on uncovering the arm. _Second day._—Dizziness at nine in the morning; her head fell forward and she imagined the floor was sinking under her; every thing turned with her. 5. At eleven, heat in the face, left side. Dull pain at the stomach, followed by desire to vomit. Cold as when she had her spasms. Hunger after dinner. In the evening, hot face. 10. Pain as if scratched, for an hour, followed by heat, at the feet. Beating pain above the left ear. Acute stitching pain in the lower gums, for an hour. Itching in the right ear, worse when stooping, for half an hour. Dreams that she is talking with dead people; very restless. 15. Sad on waking.