Dr. Mattison says that Dr. Lee and others have observed these pains in the wrists and elsewhere. I find a case reported by Dr. Benj. Lee,[70] of a very nervous woman, who had taken chloral in twenty-grain doses, nightly, for eighteen months. Conjunctivitis occurred, the dose was reduced, and the eye trouble disappeared. She again increased the dose, when pains appeared in the wrists, _running along the course of the radial arteries_. The chloral was stopped and the pains disappeared. I find no reference, in the place mentioned, to pain _girdling_ the limbs. Unfortunately, Dr. Mattison makes no reference to the source of his information, so that it is impossible to say whether this is the Dr. Lee referred to or not.[71] Anstie, as quoted by Dr. Mattison, said that he was of the opinion that many cases of supposed rheumatic or neuralgic pains would be found, on careful investigation, to be due to chloral taking, and cited the following case, in which this symptom was prominent:— “A. B., physician, began the use of chloral Feb. 1, 1873, in thirty-grain doses, to produce sleep, when kept awake by great anxieties. In two months noticed inflamed and weakened eyes, with scalding tears. Continued the drug, however, sometimes increasing the dose and repeating it. From April to August the usual amount was one drachm. In this latter month commenced using it during the day, one to three times. About Dec. 1st, began to realize the amount he was daily taking, and found it half an ounce, sometimes more. He now began to complain of severe general pains, especially about the joints, which grew worse in the moist air of London. There was no tenderness, and they were not increased by motion. Chloral did not relieve them, except when it put him to sleep. Soon after this he made a mistake in his dose, using from a strong solution, which brought on the pains with frightful severity, and Dr. Anstie was summoned. He found him with suffused eyes, haggard features, sleepless, peculiar, broken speech, lower extremities partially paralyzed, with loss of coördinating power, and excessive joint pains. An examination disclosed that he had taken more than an ounce of chloral the preceding day. It was at once withdrawn, cannabis Indica used to relieve the nervous disturbance, tonics ordered, and under this treatment he recovered.”