From eighteen superintendents of insane and five physicians of inebriate asylums, from whom I have heard, not one mentions this condition of skin about the edges of the nails. The only case of the kind reported to me is by Dr. J. W. F. Webb, of Liberty, Miss., and consisted in simple elevation of the skin at these points, without ulceration. I think we must conclude that there was some impurity of the drug used, although Dr. Kiernan avers that the drug was that furnished by Powers & Weightman. Disordered condition of the blood manifests itself in other skin affections. Judging from its effects in single or small doses in certain persons who manifest an idiosyncrasy, would lead us to entertain the possibility of skin affections from the long continued use of the drug. An artificial idiosyncrasy seems to be developed. Single doses, or the use of moderate doses for a short time, has been found to produce erythema, eczema, papular, pustular, or macular eruptions; also urticaria and herpes zoster. In a few well-authenticated instances, eruptions, exactly resembling and in some cases mistaken for those of measles and scarlatina, have been produced. They passed through regular gradations, finishing with the typical desquamation of the disease simulated. Further use of the chloral again produced the same disturbances.[87] It has been suggested that these effects are due to disorders of the digestion, as excessive acidity, etc., produced by chloral. This is disproved by the fact that in the majority of instances where they occur, the digestive organs are not disturbed. Schüle[88] believes that the majority of these skin affections are due to nervous disturbance. The following cases of hemorrhage are of interest in this connection:— Dr. A. E. M’Rae (Edinburgh _Medical Journal_, Nov., 1871) relates a case of hysteria, where he gave chloral for months. Bleeding from the lungs became so frequent and violent that twice the patient’s life was despaired of, and he had to abandon the use of the drug entirely. He refers also to a case by Dr. Husband, where fatal hemorrhage from a fibrous tumor of the womb occurred in a patient who was taking chloral. Spencer Wells (_Medical Times and Gazette_, Sept. 18, 1869) has, however, given it in cases of cancer of the womb, without producing bleeding. Turnbull (Philadelphia _Medical and Surgical Reporter_, Aug. 31st, 1872) claims that it increases the menstrual flow. Dr. C. R. Cullen, of Richmond, Va., writes me that he has seen flooding follow its use. R. C. Shettle, Physician to the Royal Berkshire Hospital, believes that its use is dangerous in labor cases, owing to the likelihood of flooding afterwards. This is totally disproved by a mass of testimony sent me by my correspondents.[89]