“‘Injector’ was, until very lately, for nearly two years, one of the victims of morphia, and during that time he five times thoroughly, and twice partially, experienced more or less of the horrible symptoms sketched by ‘Spectator’ in the _Journal_ of April 12th. The sensations were as follows: 1. A dull, gnawing pain in some decayed teeth, accompanied by a metallic taste in the mouth. 2. A pricking and tingling of the forehead and cheeks, somewhat like prickly heat; but this soon increased, spreading to the ears, neck, arms and chest (but not below the waist, although the morphia was injected into the calf of the leg). This pain soon became almost unbearable, but it was entirely eclipsed by what ‘Spectator’ calls ‘throbbing,’ but which ‘Injector’ says would be better represented by imagining twenty blacksmiths confined in his head, with each an India-rubber-headed sledge hammer, and each trying to make the best of his way out. Imagine, at the same time, that you are suffering from the first mentioned broiled feeling; that your skin feels as if about to burst; your eyes as if already started from their sockets; your lips as if they did not belong to you—then you may have a faint idea of what ‘Spectator’ wishes to describe, and what I, who have five times felt it, yet feel powerless to lay before you as I ought.” He had always thought that this condition was caused by: 1, too rapid injection; 2, too much at once; 3, the solution being too strong; and 4, by its being injected directly into a tolerably large vein. When the symptoms have occurred, he has always noticed that injection has taken place at one of two spots—probably into the same vein each time in each leg—one on each leg. Again, it only occurred when he had to inject a large quantity in a short time; and he always used a very strong solution of acetate of morphia (forty grains to the half-ounce of water). He advises that when one feels any of the symptoms coming, he should walk about as rapidly as he can. He has relieved his worst attacks in this way, and has warded off others by violent exercise in his room, as soon as he felt the pain in his teeth, or the metallic taste or the “prickly heat.” He thinks that corroboration of his belief as to the cause of the symptoms is afforded by Dr. Pepper’s description of the results of injecting milk into the veins of anæmic patients.