The case referred to by ‘Observer’ reads as follows:[22] “Scarcely has the fluid left the syringe when the most intense feeling of irritation and pricking is felt in the skin, spreading from the puncture rapidly all over the body. At the same time the skin becomes suffused with a bright blush. The heart’s action then becomes greatly quickened, and there is a throbbing, rushing feeling through the head. The hands are somewhat swollen and the lips get a glazed appearance. In one case that I had, the patient became suddenly unconscious, as if knocked down by the sudden shock; and in all the cases where these symptoms have appeared the general disturbance has been very great and the attack of a severe character. The symptoms generally subside gradually, leaving behind great pain in the head.” This gentleman gives these as the main symptoms of several such accidents that have occurred in his practice, and characterizes their occurrence as something novel and important. Dr. J. A. Houtz,[23] of Logansville, Pa., who is a staunch advocate of the hypodermic method, says: “The greatest danger is in injecting into a vein sufficiently large to carry the whole dose at once into the circulation. That can be avoided by selecting a place where the large veins are least numerous, and by injecting, say a third of a dose, and then waiting eight or ten seconds, when, if in a vein, the symptoms will show themselves. The first symptoms are a feeling of great fullness of the head and intense flushing of the face, coming on within a few seconds after the operation. Such, at least, was the case in a patient of mine.” A case of syncope and prostration is reported by Dr. E. Wenger, of Gilman, Ill. The amount of morphia used is not stated.