J. Pennock Sleightholme, L.R.C.P., Lond.,[28] reports the following case: “A young man of sound constitution and good health, who had never before taken morphia hypodermically, partly as an experiment and partly with the hope of relieving some slight restlessness, injected himself, at about 3 A.M., with one-sixth of a grain of morphia. Immediately after the injection he fell down on the floor in a state of syncope, and had slight convulsive movements on one side of the body; consciousness did not entirely leave him, and after lying still for about ten minutes he was sufficiently recovered to be able to go to the next room and help himself to a couple of glasses of sherry. After this the feeling of faintness gradually passed off, and he slept for about two hours, but on rising, at eight o’clock in the morning, the same feeling of faintness returned, accompanied with great pallor. These symptoms were relieved by a dose of brandy, but did not entirely cease until noon the same day.” A physician in the South, who is a slave to this habit, writes me: “Several times I have been unfortunate enough to puncture a vein, and to introduce some of the solution directly into it. Immediately I feel a peculiar tingling all over me, from the tips of my fingers to the ends of my toes. The skin of my head feels as if a myriad of pins were penetrating it. This feeling passes off in from three to five seconds. Sometimes it has been followed by a turgescence of the vessels of the brain, causing a great fullness and throbbing, with slight headache following.” In a most interesting and instructive letter from Dr. Wm. W. Cable, of Pittsburg, Pa., I find the following: “I have spoken of minor accidents which sometimes occurred. In all that I have seen they were caused by the injection of the morphia directly into a vein. A series of phenomena instantly take place. The patient describes the first sensations as the stinging of bees all over the body, with difficulty of respiration, and intense congestion and swelling of the face and body. In one case that I saw the face was so swollen that in five minutes all traces of the natural features were lost. This condition of affairs calls for prompt action. If possible, the patient must be kept in motion and applications of cold water be made to the face and spine. If the patient falls the limbs must be raised, and all methods used to keep the heart acting, for if you can _bridge over_ ten or twelve minutes the patient is safe. To prevent being ‘_struck_,’ as he calls it, one patient of mine carries a cord, which he throws over the arm, and if an unfavorable symptom occurs, he uses it as a tourniquet, and in a moment the result is apparent in the extravasation of the blood and the morphia from the wounded vessel. This is a safe condition, as afterward no rapid absorption can occur.” This is a companion case to that reported by Graham, where ligation of the limb proved to be of great practical importance.