[Illustration: _a_, Commencement of the Cephalic Vein; _b_, Main Trunk of the Cephalic Vein; _c_, Anterior Branch of Basilic Vein; _d_, Posterior Branch of Basilic Vein; _e_, Basilic Vein; _f_, Median Vein; _g_, Median Basilic Vein; _h_, Median Cephalic Vein; _i_, Biceps Muscle; _j_, Tourniquet. (_Agnew._)] In order to still further test the matter, he had injected muriate of pilocarpine into the ankle and into the supraclavicular region. The physiological effects of the drug (diaphoresis, salivation, etc.) were produced in both cases in about the same time, varying in different subjects from one and a half to four minutes; there was no appreciable difference. If the absorption had been by means of the lymphatics, the injection in the supraclavicular region would have produced its effects much more rapidly than that injected into the ankle. In one of the slides the section had fortunately been in the line of the puncture of the needle, and showed that considerable injury had been done to the tissues. I am firmly convinced that no physician should be held free from blame in case of accident where he has not had a ligature or tape loosely encircling the arm above the point of puncture. At the first intimation of danger this should be pulled tight and kept so for several hours, being loosened gradually, thus permitting but a gradual entrance of the drug into the general circulation. With this precaution it will be seldom necessary to treat such alarming symptoms as are here recorded. A tourniquet for this purpose is here shown. It consists of a strap or heavy tape, at one end of which is sewed a “patent buckle,” that will catch and hold at any point. In the absence of this or a skate strap with such a buckle, any cord or tape, so arranged as to be pulled tight at a moment’s warning, may be used. The treatment of such condition when already established, is summed up in one word—_stimulation_. Whiskey and ammonia hypodermically, cold affusion, electricity, when there is a battery at hand, and hot bottles to the præcordia. In some instances tetanus has followed the use of rusty needles, in one case resulting in the death of the victim, an habituè.[37] At Southsea, recently, an inquest was held upon the body of Mrs. Frampton, wife of a lieutenant and adjutant in the Royal Marine Light Infantry. The husband of deceased deposed that his wife was twenty-five years old, and that in 1871, previous to giving birth to a child, she suffered greatly from sickness. A surgeon, to alleviate this, used morphia by the hypodermic method, always injecting the solution himself. Some time since deceased assured him she had entirely given up the use of morphia. On the previous Thursday he found the deceased suffering from convulsions. She grew worse and died the following morning. Since her death several bottles had been found in her wardrobe, tied up in a parcel and secreted, together with five or six small cases, each containing a hypodermic syringe.