Absorption 5 min. 110 min. Pulse increased 8 beats. None. Pulse lowered 12 ” 10 beats. Headache 36 hours. 10 hours. Nausea 46 ” 3 ” Pulse, its nat. standard 22 ” 8 ” Incapacity to work 7 ” None. Total duration of symptoms 46 ” 11 hours. I have found that some drugs, notably jaborandi, when used hypodermically, manifest their peculiar symptoms in so short a time as one minute, no vein of any size being punctured. It is to be supposed that one drug is absorbed from the subcutaneous cellular tissue with about the same rapidity as another, but that each drug _manifests its presence_ in the circulation with a difference in point of time, according to its peculiar action, or to some idiosyncrasy of the patient. Thus, while morphia may be absorbed as rapidly as pilocarpine or jaborandi, it does not, save in certain persons or at certain times, give evidence of its presence by recognizable symptoms so early or so decidedly as the latter, _unless the patient manifests some idiosyncrasy_. From this it would appear possible, in certain cases, for a very rapid absorption to take place, and sudden overwhelming of the heart by the drug to occur without the puncture of a vein. As the needle does not go deeper than the subcutaneous cellular tissues, in a large majority of the cases the immediate treatment would be as effective in one case as in the other. At a recent meeting of the New York Pathological Society,[36] Dr. Amidon presented some microscopic specimens exemplifying the pathology of hypodermic medication. He said that although hypodermic medication had been in vogue twenty-five years, or according to the claims of some, forty years, he was not aware of any accurate investigation of the relations between the hypodermically injected mass and the skin. He had injected Prussian blue (a weak solution) into the skin of moribund subjects, and a portion of skin was excised after death. The hypodermic injection was given in what he considered the best manner, namely, the pinching up a fold of skin and introducing the needle horizontally. The hypodermic injection was found to occupy a space three and a half centimetres in diameter and one millimetre in thickness, tapering in shape. The location of the hypodermic injection varied according to the amount of adipose tissues in the subject. In those who had but little adipose tissue the hypodermic injection remained immediately below the skin, while in those who had much, the injection diffused itself. It would be seen in the specimens presented that the hypodermically injected mass lay close to the arteries and veins; sometimes it completely surrounded an artery or vein. This, together with some other experiments, proved that it was by the blood vessels and not by the lymphatics that absorption took place.