Mr. von X., sent to the Institution by Professor Westphal, had caught cold while on a journey, which brought on rheumatic pains. To relieve him injections of morphia have been administered since 1872, at first by the medical attendant, and afterward by the patient himself, and in increased quantities, the largest daily dose having amounted to sixteen grains. The symptoms showing themselves in consequence of this use were loss of appetite and sleep, excited condition, emaciation, tremor of the hands. On October 9, 1875, patient came into the Institution; he had injected morphia for the last time on the morning of the same day. At 10 P.M. patient went to bed and at once fell asleep. At 3.30 A.M. he was sick, felt very weak and prostrate, suffered from twitching in the lower extremities and diarrhœa. October 10. In the morning patient had five relaxed motions. Frequent vomiting during the whole of the day. Excitement and intense craving for morphia increases hourly. In the afternoon he talks of suicide. October 11. Patient has had no sleep during the night, but has been frequently sick. Severe vomiting continued until 11 A.M., but stopped entirely during the rest of the day. Patient complains of languid pains in the legs, severe pain in the stomach. October 12. At 10 P.M. patient suddenly started up, and in a frightened manner asked, several times, “Was not the doctor in the room just now?” only the nurse having been present. Until 12 P.M. he laid in bed quietly without speaking; he afterward raised himself up and screamed out, in great excitement, “Who is that big fellow in the next room? He is so tall that he cannot get through the door! And now he is getting taller still. Now there are several of them; they are ghosts!” His voice was trembling, his extremities in constant convulsive movements. He was quieted, but only with great difficulty. Again and again he raised himself and anxiously looked at the door. Temperature, 38.5° C. (101.3° F.). In the morning the patient addressed the superintendent, as he entered, as follows: “Ah, good morning, dear Emily. I am very glad you are coming!” While saying so he was lying down quietly. Now and then he raised his head slightly and looked at the wall for a time, as if observing something, and his lips were moving as if he was talking to somebody. In the course of the day he vomited considerably, several times. Patient feels very weak, the speech is unintelligible, the tremor has increased. He entered into a short conversation, and thinks himself better than yesterday. Although very tired he cannot get to sleep. Pulse was strong throughout the day. Auscultation and percussion of the lungs and heart showed a normal condition. The bladder was empty and no urine was passed until 5 P.M. Several relaxed motions.