On commencing the treatment, the patient is required to give up all money or valuables he may have about him, for which he is given a receipt. He is then undressed by a nurse, wrapped in a blanket, and taken to the bath-room, where he is given a bath. While this is being done, another nurse, under the supervision of the physician, searches everything the patient has brought with him, including the clothes just removed, and takes away any morphine or opium that may have been secreted, as, also, scissors, knife, needles, etc. The search must be very thorough, as I have known patients to sew packets of morphine into the lining and waistbands of their clothing. The patient is then brought back to his room, the nurse fully instructed, and the treatment by _rapid_ reduction commenced. The physician himself administers the drug, whether by the mouth or by the skin. I usually reduce the quantity used in twenty-four hours one-third, sometimes one-half, the first day. The following case will illustrate the plan pursued:— Miss B. (sent to me by Drs. Claggett and Walls, of Baltimore), single, aged twenty-seven, born in Virginia. Tall, thin, emaciated. Weight about ninety-eight pounds. Complexion reddish. Dark-brown hair, grayish-blue eyes. Height five feet seven and one-half inches. Extremely nervous temperament. Pupils irregular and contracted. Entered my house for treatment October 16, 1880. Had been taking morphia subcutaneously for eighteen months. It was first given her by a physician, to relieve the intense pain of an attack of pelvic cellulitis. At the end of the treatment, being still a sufferer, she procured a syringe, and continued the injections herself, gradually increasing the dose until the daily amount reached six grains. Sometimes it would be less than this. She was accustomed to take three injections in the twenty-four hours; one in the early morning, one about midday, and one late in the afternoon. She ceased to menstruate three months after she commenced to use the drug, and had not menstruated up to the time of admission. No history of alcoholic excesses in ancestors. Has one sister who is extremely nervous, and a brother just recovering from paralysis of one side of the face. Her face is dotted with pustules, as also the chest. Body and limbs marked by cicatrices of old and recent punctures. Appetite fair, bowels constipated. Somewhat lethargic and stupid in mind, but, withal, very nervous. Is despondent, and cries easily, but is very anxious to abandon the habit. There is some vaginismus and spasm of the sphincter of the bladder. October 15, 1880. Seen by Dr. T. Addis Emmet, who pronounced her to be free from all uterine and ovarian disease, beyond the remains of an old pelvic cellulitis, by which the uterus was drawn somewhat to one side. He recommended the injection of large quantities of hot water.