The patient whom I treated by the sudden deprivation of the drug was a married lady, aged forty-five, stout and flabby. She had been using morphia by the mouth for nearly sixteen years, in the last year taking from seven to ten grains daily. I saw her one afternoon and commenced treatment the next morning. The drug was taken away at once. That day she began to complain of salivation, dyspnœa, intense grinding pains in the calves of the legs, headache, pain about the heart and a strong desire for morphia. The first night she did not sleep at all. Was feverish and restless, tossing from side to side of the bed, moaning, occasionally crying out. Toward morning she became delirious, ran about the room, screamed, attacked the nurse, attempted to jump out of the window and battered at the door. By 8 A.M. she had sunk into a stupor, from which she was occasionally roused by fits of sneezing. A hard, dry, hacking cough supplemented the dyspnœa. Nausea was intense and vomiting frequent. She, on the third day, knew none of those about her, saw imaginary men and animals, wept, laughed, moaned and muttered incoherently. Sordes formed upon teeth and lips; the fæces and urine were passed in the bed. In this state she remained for six weeks, in spite of every effort to arouse her. All day in a typhoid condition; at night staggering about the room, screaming, crying and attacking the nurse. In the seventh week she began to recognize faces, although her hallucinations and delusions continued. She very slowly regained strength. Pains persisted in the limbs. There was trembling of the hands and tongue, inability to read, and she would cry at the most trivial thing. Her nights were filled with terrible sights and dreams, the memory of which lasted her the whole of the following day. Several times there was severe collapse, necessitating the free use of stimulants and an occasional small dose of opium. During all this time tonics, concentrated food, baths and electricity were given. _It was fully four months before her mind regained its balance._ She was seen once, in consultation, by Dr. G. H. Wynkoop, of this city. That was my first case, and I shall never try the experiment again. I know of several instances where physicians have tried this plan and abandoned it. Her urine contained both sugar and albumen in large amount. This afterward wholly disappeared. Here is further testimony as to the efficacy of the treatment by sudden deprivation:—