The use of the drug being discontinued, attention should be at once directed to the treatment of the original affection _or of any disease that may lead the patient to again return to the use of the drug_. There are, too, certain troublesome symptoms, about some of which I have already spoken, that come on a few days after the opium or morphine is stopped. The most troublesome of these is “soreness of the throat,” consisting in congestion of the pharynx, tonsils, larynx and vocal cords. There is a sensation of tickling and a short, dry, annoying cough, that comes on in paroxysms and is especially troublesome at night. It is best treated by the local application of nitrate of silver (twenty to forty grs. to the ounce) and five-drop doses of benzoic acid given several times daily. The insomnia is usually relieved by exercise better than by drugs, although I have often found bromide of potassium and hyoscyamus of service. On no account use chloral hydrate, or give stimulants at bedtime. Exercise is by far the best remedy. Walking, running, making garden, etc., sufficient to tire the patient out thoroughly, is an almost certain sleep producer, appetizer and hastener of tissue metamorphosis. The cold pack or a hot bath at bedtime often proves of service. The appetite usually needs no stimulation by drugs. It is, as a rule, ravenous for the first few weeks after the morphine is stopped, so much so that ten-grain doses of pepsine will often be found necessary after each meal, the patients usually over eating. As a rule, I give the following mixture, as much for its effect on the nervous system as for the appetite:— ℞. Strychniæ sulph., gr. ss. _vel_ gr. j Tinct. gentian co., Tinct. cinchona co., āā ℥ ij. M. SIG.—One drachm half an hour before meals. If anæmic, nothing acts so well as the muriated tincture of iron, which usually contains a trifle of arsenic, in from fifteen to forty-drop doses, three times a day, _after meals_. It should be given in half a goblet of water. Cod-liver oil is also of great benefit, especially if there is combined with it minute doses of the iodide of arsenic. Seminal emissions and priapism in males will right themselves. Females who suffered from leucorrhœa before they commenced using opium or morphine, and who stopped during the time they were taking it, as, also, those who have never had such a discharge, are usually troubled with a white, ropy matter passing away from them in large amount. This is sometimes accompanied by severe, labor-like pains. Vaginal injections of a strong infusion of white oak bark are called for, to be followed by the use of the following on the top of pads made of borated or absorbent cotton:— ℞. Tinct. iodin comp., ℥ ss Glycerin, ℥ ij. M.