Dr. W. M. Compton,[45] Medical Superintendent, Insane Asylum, Jackson, Miss., says that he has given twenty to thirty-grain doses of chloral hydrate nightly, for years, to noisy patients, without observing any ill effects. Dr. J. H. Nordlin,[46] of Rome, Ga., has given it in combination with bromide of potassium, capsicum and ammonia, in asthma, for a long time, without any ill effects. A correspondent of the London _Lancet_,[47] a medical man, says that, for sleeplessness, he has been obliged to take twenty-grain doses of chloral at bedtime, for upward of four years, without any bad consequences whatever. Dr. J. G. Thornley[48] has used chloral in the treatment of insane persons, continuing its use for from six months to two years, without any ill effects. Dr. Schlaugenhausen, First Assistant Physician to the Lunatic Asylum, Hall, Tyrol, writes me that in a case of insanity he gave thirty grains of chloral every night, for six years, without any perceptible bad effect. He says that he has never seen a case where there was a morbid craving for chloral, such as is seen from opium or morphine. Dr. John Wirtinger, of Ybbs on the Danube; Dr. Reiman, of Kiev, Russia, and Dr. Fr. Akland, of Stockholm, Sweden, write the same. Dr. A. Ady,[49] of West Liberty, Iowa, gave chloral in a case of chronic diffuse nephritis, for nearly a year and a half, without any bad results and with no tendency to the formation of a habit. Bidlack[50] relates a case where this drug was used for a year, with no bad effects. Lawrence Turnbull[51] gave chloral, in medicinal doses, for one year, as a sedative and narcotic. Its use was stopped at once, without any ill effects whatever. Dr. Blackwood[52] used thirty grains three times a day, in combination with bromide of potassium, for three months. No bad effects beyond slight conjunctivitis. No evil effects followed the withdrawal of the drug. Dr. Carlos F. MacDonald[53] writes: “As regards the so-called ‘chloral habit,’ I can only say that I have used chloral very largely in my practice—commencing with its introduction to the notice of the profession in America—and I have yet to meet with a case.” A physician, who does not wish his name used, took twenty grains at bedtime, for insomnia, for nearly two years and a half, without ill effect. Professor A. A. Smith, of Bellevue College, this city, writes me: “A lady of an extremely nervous temperament had it administered to her during an attack of typho-malarial fever. This was seven years ago, and she has taken it every night of her life since. Usually ten grains suffices, but sometimes she takes thirty grains. It has had no perceptible bad effect. She seems perfectly well. I have, time and again, tried to wean her from the habit, but to no purpose, and I am quite certain that the drug has never yet done her any harm.”