"Not all the institutions of learning founded in Mexico in the sixteenth century can be enumerated here, but it is not too much to say that in number, range of studies and standard of attainments by the officers they surpassed anything existing in English America until the nineteenth century. _Mexican scholars made distinguished achievements in some branches of science, particularly medicine and surgery, but pre-eminently linguistics, history and anthropology._ {145} Dictionaries and grammars of the native languages and histories of the Mexican institutions are an imposing proof of their scholarly devotion and intellectual activity. Conspicuous are Toribio de Motolinia's 'Historia de las Indias de Nueva España,' Duran's 'Historia de las Indias de Nueva España,' but most important of all Sahagun's great work on Mexican life and religion." The scientific products of these universities in America are interesting because almost as a rule we know absolutely nothing about them in English America, and, therefore, conclude there must have been none. The first book written on a medical topic in America was the "Secretos de Chirurgia," written by Dr. Pedrarias de Benavides, which was published at Valladolid in Spain in 1567. The first book on medicine actually published in this country was "Opera Medicinalia," by Francisco Bravo. [Footnote 10] On Columbus' second expedition, however, a Dr. Chança who had been physician-in-ordinary to the King and Queen of Spain, was sent with the expedition as what we would now call a scientific attaché. On his return he wrote a volume of scientific observations that he had made in America. Some of these were doubtless written while he was over here, though the book was published in Spain. Dr. Ybarra of New York recently published a résumé of this in the Smithsonian Publications and an article on it in the _Journal of the American Medical Association_. {146} It shows very well how wide were the scientific interests of the physicians of the time and how ardent their investigation of science, for there is scarcely a phase of modern science that would be touched on by the corps of scientists now attached to such an expedition which does not receive some serious treatment in Dr. Chança's book. Thus early did the Spanish-Americans take up scientific investigation seriously. [Footnote 10: Published in Mexico, 1570.]