The most malignant and intractable of tumours is the Carcinomatous.
This term is applied to the disease in its occult state, whilst Cancer,
a term pretty indiscriminately employed, may denote its condition
after ulceration. The word scirrhus is often used synonymously with
carcinoma; but the former has been, and still is, improperly employed
to denote indurations and enlargements of structures in all situations,
and has been altogether so much abused as to warrant its being erased
from the nomenclature of diseases. Carcinoma seldom occurs before the
age of thirty, and generally not till a later period of life; there are
instances, however, of its appearance at a much earlier period. Very
frequently it is not primary, but supervenes on adventitious formations
originally of an innocuous character, and which might have long
remained so. All tumours, though at first not of a hurtful tendency,
are liable to assume malignant action, either from a constitutional
cause, from external injury, or from latent disposition. When it
occurs in newly-formed parts, the surrounding cellular substance is
frequently condensed and thickened, so as to form a cyst round the
tumour; and when it supervenes on chronic tumours, the cysts which
enveloped these remain, for some time, as entire and distinct as
formerly, though the character of their contents is remarkably changed.
Afterwards the cyst may be contaminated with the same disposition as
its contents, assume the same action, and be converted into a similar
substance. When the disease is seated in the lymphatic glands, the
cyst is at first distinct, and gradually disappears; whilst in this
affection of the conglomerate glands a cyst is at no time perceptible,
and the cancerous matter insinuates itself, and is lost, in the
surrounding substance. The carcinomatous tumour is of great density,
and communicates a peculiarly grating sensation and noise when cut. In
its section there appears a central point, or nucleus, from which dense
ligamentous bands of a white colour proceed towards the circumference,
diverging in regular succession, as rays of light from a luminous
body; or the larger bands subdivide into smaller ones, which follow
a similar course with their parent trunk, or ramify regularly; or,
from the first, follow an irregular and intricate course, uniting with
and crossing one another, so as to present a retiform appearance. In
general, the interposed substance is of a greyish colour, extremely
dense, and generally homogeneous, though sometimes granular. Often
the ligamentous bands are so numerous, and so intimately interwoven,
as to leave little or no room for any intervening substance.
Sometimes, and most frequently in the advanced state of the tumour,
the greyish matter appears to have been broken down and removed,
its situation being occupied by a glairy or turbid fluid, by a soft
pulpy substance, or by blood; the parietes of such cysts are formed
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