Dr. Jenner did not marry till March 6, 1788, when Miss Catherine Kingscote, a lady belonging to a well-known Gloucestershire family frequently furnishing representatives to Parliament, became his wife. The union was very happy, but Mrs. Jenner’s delicate health for many years caused great anxiety and needed constant attention. In 1792 Jenner became M.D. of St. Andrews, with the view of giving up much of his fatiguing general practice. In 1794, at the age of forty-five, he suffered from a severe attack of typhus fever, which threatened to prove fatal. At this time the experiments in proof of vaccination had not been made, and if he had died, the world in all probability might have waited long for the introduction of this great novelty. Many who learn that vaccination was made known to the world in 1798, when Jenner was forty-nine years old, do not know that the subject attracted his attention in his youthful days as a country surgeon’s apprentice, and that his faculties were ever after engaged upon the matter at every convenient opportunity. He repeatedly mentioned the subject of cowpox to his great teacher, John Hunter, when studying with him in London. Hunter never damped the ardour of a pupil by suggesting doubts or difficulties; but it does not appear that he was specially impressed by what he heard. Yet he made known Jenner’s information and opinions both in his lectures and to his friends. But for many years Jenner’s ideas were poohpoohed by medical and other authorities whom he met in his country practice. They believed many had had smallpox after cowpox, and that the supposed protective influence of the latter was due to something in the constitution of the individual. Not till 1780 did Jenner fully disclose to his devoted friend Edward Gardner his hopes and fears about what he felt to be his great life-work. He then described to him the various diseases which attacked milkers when they handled diseased cows, and especially that form which afforded protection against smallpox; and with deep and anxious emotion expressed his hopes of being able to propagate this latter form from one human being to another, so as to bring about the total extinction of smallpox.