In the year 1773 Mr. Hunter suffered the first open onset of the disease which occasioned him such acute pain and distress for many years, in an attack of spasm accompanied by cessation of the heart’s action apparently for three quarters of an hour. During the attack, however, sensation and voluntary actions were kept up, and he was able to continue respiring by voluntary effort. In the next few years the attacks were somewhat rare; but from 1783 onwards he was subject to severe angina pectoris whenever mentally agitated. In 1777 a constant giddiness or vertigo seized him on account of his being called upon to pay a large sum of money for a friend for whom he had become security, at a time when it was exceedingly inconvenient to do so. This illness led him to visit Bath in the autumn, leaving Mr. Bell and Mr. Home to catalogue his museum. At Bath Dr. Jenner visited him and was surprised at his altered appearance, and here first diagnosed his case as dependent upon an organic affection of the heart: but he did not tell Hunter his diagnosis, fearing an injurious effect. Returning to town, and soon recovering his usual health and vigour, Mr. Hunter published in 1778 the second part of his Treatise on the Teeth, dealing with their diseases. In 1779 a paper contributed to the Royal Society on the hermaphrodite black cattle or free martin gave him occasion to describe hermaphroditism in general. In 1780 occurred the unfortunate controversy with his brother, in regard to the discovery of the utero-placental circulation, to which we have already referred. The estrangement which followed was extreme, and protracted till the elder brother lay on his deathbed. After his brother’s death, however, which occurred just at the conclusion of John Hunter’s course of lectures, when he had finished his lecture, he still seemed to have more to say; and at length, appearing as if he had just recollected something, he began, “Ho! gentlemen, one thing more: I need not remind you of ——: you all know the loss anatomy has lately sustained.” He was obliged to pause and turn his face from his hearers. At length recovering himself, he stated that Mr. Cruickshank would occupy the place of Dr. Hunter. This, and a few words more, were not spoken without great emotion, nor with dry eyes. The scene was so pathetic, that a general sympathy pervaded the class; and though all had been preparing to leave, they stood or sat motionless for several minutes.