GREGORY, ST, OF NYSSA (c. 331-c. 396), one of the four great fathers of the Eastern Church, designated by one of the later ecumenical councils as "a father of fathers," was a younger brother of Basil (the Great), bishop of Caesarea, and was born (probably) at Neocaesarea about A.D. 331. For his education he was chiefly indebted to his elder brother. At a comparatively early age he entered the church, and held for some time the office of anagnost or reader; subsequently he manifested a desire to devote himself to the secular life as a rhetorician, an impulse which was checked by the earnest remonstrances of Gregory of Nazianzus. Finally, in 371 or 372 he was ordained by his brother Basil to the bishopric of Nyssa, a small town in Cappadocia. Here he is usually said (but on inadequate data) to have adopted the opinion then gaining ground in favour of the celibacy of the clergy, and to have separated from his wife Theosebia, who became a deaconess in the church. His strict orthodoxy on the subject of the Trinity and the Incarnation, together with his vigorous eloquence, combined to make him peculiarly obnoxious to the Arian faction, which was at that time in the ascendant through the protection of the emperor Valens; and in 375, the synod of Ancyra, convened by Demetrius the Arian governor of Pontus, condemned him for alleged irregularities in his election and in the administration of the finances of his diocese. In 376 he was deprived of his see, and Valens sent him into exile, whence he did not return till the publication of the edict of Gratian in 378. Shortly afterwards he took part in the proceedings of the synod which met at Antioch in Caria, principally in connexion with the Meletian schism. At the great ecumenical council held at Constantinople in 381, he was a conspicuous champion of the orthodox faith; according to Nicephorus, indeed, the additions made to the Nicene creed were entirely due to his suggestion, but this statement is of doubtful authority. That his eloquence was highly appreciated is shown by the facts that he pronounced the discourse at the consecration of Gregory of Nazianzus, and that he was chosen to deliver the funeral oration on the death of Meletius the first president of the council. In the following year, moreover (382), he was commissioned by the council to inspect and set in order the churches of Arabia, in connexion with which mission he also visited Jerusalem. The impressions he gathered from this journey may, in part at least, be gathered from his famous letter _De euntibus Hierosolyma_, in which an opinion strongly unfavourable to pilgrimages is expressed. In 383 he was probably again in Constantinople; where in 385 he pronounced the funeral orations of the princess Pulcheria and afterwards of the empress Placilla. Once more we read of him in 394 as having been present in that metropolis at the synod held under the presidency of Nectarius to settle a controversy