The Royal Jennerian Society having failed, the national vaccine establishment was founded, for the extension of vaccination, in 1808. Jenner spent five months in London for the purpose of organizing it, but was then obliged, by the dangerous illness of one of his sons, to return to Berkeley. He had been appointed director of the institution; but he had no sooner left London than Sir Lucas Pepys, president of the college of physicians, neglected his recommendations, and formed the board out of the officials of that college and the college of surgeons. Jenner at once resigned his post as director, though he continued to give the benefit of his advice whenever it was needed, and this resignation was a bitter mortification to him. In 1810 his eldest son died, and Jenner's grief at his loss, and his incessant labours, materially affected his health. In 1813 the university of Oxford conferred on him the degree of M.D. It was believed that this would lead to his election into the college of physicians, but that learned body decided that he could not be admitted until he had undergone an examination in classics. This Jenner at once refused; to brush up his classics would, he said, "be irksome beyond measure. I would not do it for a diadem. That indeed would be a bauble; I would not do it for John Hunter's museum." He visited London for the last time in 1814, when he was presented to the Allied Sovereigns and to most of the principal personages who accompanied them. In the next year his wife's death was the signal for him to retire from public life: he never left Berkeley again, except for a day or two, as long as he lived. He found sufficient occupation for the remainder of his life in collecting further evidence on some points connected with his great discovery, and in his engagements as a physician, a naturalist and a magistrate. In 1818 a severe epidemic of small-pox prevailed, and fresh doubts were thrown on the efficacy of vaccination, in part apparently owing to the bad quality of the vaccine lymph employed. This caused Jenner much annoyance, which was relieved by an able defence of the practice, written by Sir Gilbert Blane. But this led him, in 1821, to send a circular letter to most of the medical men in the kingdom inquiring into the effect of other skin diseases in modifying the progress of cow-pox. A year later he published his last work, _On the Influence of Artificial Eruptions in Certain Diseases_; and in 1823 he presented his last paper--"On the Migration of Birds"--to the Royal Society. On the 24th of January 1823 he retired to rest apparently as well as usual, and next morning rose and came down to his library, where he was found insensible on the floor, in a state of apoplexy, and with the right side paralysed. He never rallied, and died on the following morning.