The third form in which proteids may be consumed in the body is in the actual replacement of worn-out cells. The skin, the hair, and the mucous or lining membranes of the body-cavities are constantly being cast off on the external surface, new cells being formed underneath. When cells within the interior of the body have become injured, or have passed their usefulness, they are removed by the phagocytes or white blood-corpuscles, and must be replaced by other cells. In the case of bacterial infections, as tumors, boils, or contagious dis-eases, the bacteria feed upon the proteids of the blood. The white blood corpuscles are destroyed in the conflict, or effort to remove the intruders, and all these substances must be replaced by proteids from food. THE ACTION AND THE COMPOSITION OF PROTEIDS [Sidenote: Determination of income and outgo of nitrogen] The gain or loss of body-proteids is indicated by the gain or loss of nitrogen. The income of nitrogen can be ascertained by analyzing the food. The outgo of nitrogen is computed by analyzing the products excreted from the body. If the body at the beginning and at the end of an experimental period is carefully watched, and the income and the outgo of nitrogen determined, we can compute the amount of gain in the body that is nitrogenous tissue. The other gain or loss of body-weight must be fat. These calculations cannot be made exact, owing to the amount of food and water that may be in the digestive organs at the time the various weighings are made. [Sidenote: Why proteids are converted into peptones] We have learned that in the digestive tract foods are converted into a soluble form of proteid known as peptone. The purpose of this conversion and the fine subdivisions of food produced by the various digestive juices are to reduce it to a form which will readily pass through the walls of the alimentary canal. [Sidenote: Nitrogen and urea] This is all that was known about proteid metabolism until within very recent years. The older scientists followed proteid digestion until the soluble peptone stage was reached, at which point all track was lost of the chemical changes and processes until the nitrogen was again excreted by the kidneys in the form of urea. No scientist attempted to explain how the radically different proteids, such as egg-albumin, milk-casein, and wheat-glutin could appear in the body as blood-globulin, brain-lecithin, or as a myosis of the muscles. The history of all these investigations cannot be fully explained here, but the discussion must be confined to that which actually takes place in the metabolism of proteids. [Sidenote: Composition of proteids] Proteids, as the student will remember, contain carbon, hydrogen, oxygen, and nitrogen, and sometimes small quantities of sulfur, phosphorus, or iron. These forms of proteids are now known to be chemically changed, by the digestive enzyms of the intestines, into simpler compounds containing these same elements.