Epidemic Respiratory Disease: The pneumonias and other infections of the repiratory tract accompanying influenza and measlesOpie, Eugene L. (Eugene Lindsay)
History
Epidemic Respiratory Disease: The pneumonias and other infections of the repiratory tract accompanying influenza and measles
=Peribronchiolar Consolidation.=—In many instances of bronchopneumonia,
usually in association with lobular or confluent consolidation, small
firm nodules of consolidation are clustered about the bronchioles (Fig.
2). These nodular foci of consolidation are usually 1.5 to 2 mm. in
diameter, being sometimes slightly smaller or slightly larger. They are
usually gray and occasionally surrounded by a red halo; sometimes they
are yellowish gray. They are clustered about the smallest bronchial
tubes to form groups which are from 0.5 to 1 cm. across. A group of
nodular foci of consolidation occupies the central part of a lobule of
lung tissue. When pneumonia has been of short duration these foci are
fairly soft and not sharply defined, and in many instances this form of
bronchopneumonia is first recognized by microscopic examination. When
the disease has lasted from ten days to two weeks, the consolidated
nodules are very firm and sharply circumscribed, closely resembling
tubercles. When they have assumed this character, microscopic
examination shows that chronic changes indicated by new formation of
interstitial tissue have occurred.
The lesion may be designated peribronchiolar consolidation. It has
occurred usually in association with other types of pneumonic lesion in
61 instances, being recognized at autopsy in 18 and by microscopic
examination in 43.
[Illustration:
Fig. 2.—Acute bronchopneumonia with nodules of peribronchiolar
consolidation and purulent bronchitis. Autopsy 429.
]
In association with this lesion there are almost invariably severe
lesions of the bronchi. Purulent bronchitis was noted in 47 of the 61
instances, in which this nodular bronchopneumonia was found at autopsy.
An index of the severity of the bronchial injury is the frequency with
which bronchiectasis has occurred; dilatation of small bronchi was
observed in 24 instances. In 10 instances the bronchi were encircled by
conspicuous zones of hemorrhage.
In association with this peribronchiolar lesion the lung is often
voluminous and fails to collapse on removal from the chest. Pressure
upon the lung squeezes from the smallest bronchi, both in the
neighborhood of the nodular consolidation and elsewhere, a droplet of
viscid, semifluid mucopurulent material. The presence of this tenacious
material throughout the small bronchi doubtless explains the failure of
the lung tissue to collapse. Interstitial emphysema has been present in
some of these lungs.
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