Epidemic Respiratory Disease: The pneumonias and other infections of the repiratory tract accompanying influenza and measlesOpie, Eugene L. (Eugene Lindsay)
History
Epidemic Respiratory Disease: The pneumonias and other infections of the repiratory tract accompanying influenza and measles
The hemorrhagic and edematous consolidation of the early pulmonary
lesions of influenzal pneumonia is their most distinctive feature. Red
confluent lobular pneumonia is frequently found in those who have died
within the first week following the onset of influenza. The lungs are
voluminous and heavy and may weigh as much as 1,500 grams; the pleura
which overlies the consolidated area is blue or plum colored and usually
shows scant if any evidence of pleurisy. Scattered patches of
consolidation are accurately limited to lobules, but in addition there
are large areas often involving the greater part of the lobes and not
infrequently situated in the lowermost part of the lower lobes. This
confluent consolidation may be obviously limited by lobule boundaries.
The consolidated tissue is deep red and laxly consolidated; red serous
fluid escapes from the cut surface. The lesion not infrequently occurs
in association with hemorrhagic peribronchiolar pneumonia.
The histology of this confluent lesion has been studied in Autopsies
242, 244, 303, 336, 464, 474 and 506. The histology varies, because, in
some instances, leucocytes, in other instances, fibrin, is abundant, but
the presence of red blood corpuscles in large number within the alveoli
gives a red color to the consolidated tissue. In these cases
pneumococci, associated in the lungs or in the bronchi with B.
influenzæ, have been the cause of pneumonia. In two autopsies studied
histologically (Autopsies 274 and 478) there was red lobular and
confluent pneumonia and the blood and lungs contain hemolytic
streptococci demonstrated by cultures; microscopic examination showed
the presence of a widespread necrosis of the lung tissue.
In the group of autopsies in Table XL there was red confluent lobular
pneumonia. These autopsies are separated from those just cited because
there was no histologic examination of the tissue.
TABLE XL
═════════════════╤═════════════════╤═════════════════╤═════════════════
NO. OF AUTOPSY │ BACTERIOLOGY OF │ BACTERIOLOGY OF │ BACTERIOLOGY OF
│ HEART’S BLOOD │ LUNGS │ BRONCHUS
─────────────────┼─────────────────┼─────────────────┼─────────────────
289 │ Pneum. IV │ Pneum. IV │ Pneum. IV, B.
│ │ │ inf., staph.
297 │ │ Pneum. IV, B. │ Pneum. IV, B.
│ │ inf. │inf., S. hem. (a
│ │ │ few)
306 │ │ │
339 │ Pneum. IV │ │
364 │ S. hem. │ │
418 │ Pneum. atyp. II │Pneum. atyp. II, │
│ │B. inf., S. vir. │
424 │ │ Pneum. IV. │
─────────────────┴─────────────────┴─────────────────┴─────────────────
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