In East Prussia small-pox broke out very frequently in the city and vicinity of Königsberg. According to Guttstadt, small-pox patients, in consequence of the proximity of the Russian border, kept coming to the hospital in Königsberg, into which twelve persons suffering from the disease were received between January 1 and August 1, 1870. The first prisoners-of-war arrived at Königsberg on August 15, 1870, and among them was a small-pox patient. Shortly afterwards two more cases of the disease occurred among the prisoners. The first case among the civil population occurred in the hospital on September 2. Owing to the constant intercourse between the prisoners and the civil inhabitants the epidemic spread very rapidly. The districts surrounding Königsberg were very severely attacked in the year 1871, while the more remote districts, especially those along the boundary of West Prussia, were not attacked until the year 1872. In the districts around Königsberg the mortality per 10,000 inhabitants was as follows: 1871. 1872. Königsberg (city) 49·8 3·6 Königsberg (vicinity) 78·4 13·3 Labiau 42·4 30·6 Wehlau 103·1 8·9 Insterburg 32·2 47·3 Fischhausen 38·7 17·9 In the districts of East Prussia more remote from Königsberg the following number of deaths per 10,000 inhabitants were reported: