Printing was established at Rome in 1467 by the removal of Sweynheym and Pannartz from Subiaco. Five books are recorded to have been printed there in that year; two classics (Cicero's "De Oratore" and "Epistolæ ad Familiares"), two editions of the fathers, and one grammatical work. In 1468 six more make their appearance, one classical, three patristic, one theological, and one medical. In 1469 commences the great run upon classical writers, which continued for some years. Of the twelve books enumerated by Panzer as produced in this year, all but one are classics, and the apparent exception is a defence of Plato by Cardinal Bessarion. All but one are printed by Sweynheym and Pannartz, with prefaces by the Bishop of Aleria as editor-general. This striking development of activity indicates the first organised attempt to monopolise a special department of the book-trade, which might possibly have succeeded if Rome had then, as now, been the capital of an united Italy. The other Italian cities, however, had no intention of being excluded from the practice of the new art, and the same year witnessed the introduction of typography into its true Italian metropolis, Venice, combined, however, with an audacious attempt to obtain a monopoly. Joannes de Spira, the first printer in Venice, not content with obtaining protection for his publications, claimed and obtained the sole right of printing books in the city for five years. Men had evidently as yet but little conception of the importance of the new art; but the death of the printer within the year released the Venetian State from the obligation it had so inconsiderately undertaken, and it was by this time sufficiently enlightened not to renew it in favour of his brother Vindelinus, who, however, remained for some time among the most distinguished of Venetian printers.[149:1]