Notwithstanding this general principle with regard to heredity, there are a number of striking observations which show that even unimportant peculiarities may occur from generation to generation, though it is not always easy to decide where the peculiarity originated. The well-known example of the occurrence of six toes has already been mentioned, and is an oft-quoted bit of evidence as regards hereditary transmission. An extra finger on the hand, or some portion of an extra finger, at least, comes in the same category. Not long since it was pointed out that harelip is another of these peculiarities that readily lends itself to hereditary transmission. Recently there was the report of a family into which there were born four girls with harelip and cleft palate, and three boys not showing any trace of these deformities. Often when in such cases there is no definite history of harelip, it is found that in either one of the parents there is a very high arched palate and a thin upper lip, showing that the normal occlusion of the cleft which exists here during foetal development is not quite perfect, and this peculiarity may be traced for several generations back, with an occasional occurrence of harelip as an exaggerated example of the faulty tendency not to produce sufficient tissue in this neighbourhood for the proper closure of the embryonic cleft. An even more striking manifestation of a physical anomaly, as a family trait, is the condition known as hemophilia. This {124} tendency to bleed easily, so that a slight scratch, or the pulling of a tooth, may give rise to fatal hemorrhage, occurs, as a rule, only in males, but is transmitted through the female line. It is in the mother's male relatives that the history of its previous occurrence is found, and the tendency usually can be traced through several generations, until it is lost in vague tradition. It is no wonder, with such examples before them as six-toedness, harelip, and hemophilia, that physicians have been ready to accept heredity of qualities in the moral order, traits of character and disposition, and pathological tendencies to crime or passion or indulgence. One of the most frequently discussed conditions of supposed pathological inheritance of this order is dipsomania. Everyone has heard it said, "Poor fellow, how can he help it; his father was a drunkard before him." As we have already said, in such direct cases inheritance is absolutely unproven. An alcoholic father may transmit a very weak physical constitution to his children, and this may prove inadequate to enable them to withstand the emotional strain and worry of modern great city life, and, as a consequence, they may take to alcohol for consolation until the habit is formed, and then the craving for stimulants supplies the place of any hereditary influence that may be supposed to be needed.