The principle thus displayed in the humbler forms of life, is traceable during the development of the higher; though being here soon masked by the assumption of the hereditary type, it cannot be traced far. Thus the "mulberry-mass" into which a fertilized ovum of a vertebrate animal first resolves itself, soon begins to exhibit a difference between the outer and inner parts answering to the difference of circumstances. The peripheral cells, after reaching a more complete development than the central ones, coalesce into a membrane enclosing the rest; and then the cells lying next to these outer ones become aggregated with them, and increase the thickness of the germinal membrane, while the central cells liquefy. Again, one part of the germinal membrane presently becomes distinguishable as the germinal spot; and without asserting that the cause of this is to be found in the unlike relations which the respective parts of the germinal membrane bear to environing influences, it is clear that we have in these unlike relations an element of disturbance tending to destroy the original homogeneity of the germinal membrane. Further, the germinal membrane by and by divides into two layers, internal and external; the one in contact with the liquefied interior part or yelk, the other exposed to the surrounding fluids: this contrast of circumstances being in obvious correspondence with the contrast of structures which follows it. Once more, the subsequent appearance of the vascular layer between these mucous and serous layers, as they have been named, admits of a like interpretation. And in this and the various complications which now begin to show themselves, we may see coming into play that general law of the multiplication of effects flowing from one cause, to which the increase of heterogeneity was elsewhere ascribed.[9]