At this moment, however, the victory of Bicocca retrieved the fortunes of Charles. In March, Lautrec had advanced against Milan, then held by Colonna for the Emperor. Sforza at once marched from Pavia to relieve Colonna, and, after some manœuvring, entrenched himself in the Villa Bicocca, some few miles from the city. The position was a strong one. But the Swiss showed insubordination, and insisted on an attack, which Lautrec dared not refuse. The Swiss had miscalculated their powers, and were repulsed. Lautrec, who had made a detour with his French soldiers, with the object of taking the position in the rear, from whence alone an entrance seemed practicable, was delayed, and had to face the united force of the enemy, flushed as they were with victory over the Swiss. He was beaten back with serious loss, and the imperial forces remained masters of the first important battle of the war. The defeat ruined the French cause. They still held the citadel of Milan, and the town of Novara, but had to evacuate the rest of the Milanese, and shortly after (May 30), they were driven from Genoa. The Doge, Ottavio Fregoso, the leader of the French party, was taken prisoner, as well as Pedro Navarra, the great Spanish general, who had been driven into the service of France by the niggardliness of Ferdinand. Antonio Adorno was set up as Doge, as a vassal of Charles--and France thus lost the important harbour which hitherto had given her an easy entrance into Italy. The victory of Charles only served to increase Adrian’s desire for peace, but neither of the rivals would listen. In June, 1522, Charles, then on his way to Spain, signed the treaty of Windsor. Henry and the Emperor agreed that the humiliation of Francis was the necessary preliminary to a war against the Turk. They accordingly promised to engage in a joint attack on France, and to solicit the alliance of the Pope and Venice. Even the fall of Rhodes, the important outpost against the Moslem, held by the knights of St. John in the Mediterranean (December 20), although it caused great dismay in Europe and bitter grief to Adrian, did not cause the two great powers to forego their quarrels; and finally in August, Adrian, warned by the intrigues of the French partisans in Italy that any idea of mediation was vain, and that if the French were victorious the Papal States would be in danger, joined in a defensive league with the Emperor, a league which included England, Milan, Genoa, Florence, and Venice. Six weeks afterwards, Adrian died (September 14, 1523). In spite of his narrowness and want of statesmanship, Adrian was a good man, and earnestly desired reform. Yet the desire only earned him the inveterate hatred of the Cardinals, and of the mob of Rome, who decorated the door of his physician with a wreath, dedicated ‘to the liberator of his country.’ The pathetic failure of Pope Adrian is perhaps the best vindication of Luther’s revolt. § 5. _Luther and the Council of Regency._