Eight years before this bull, Bartholomew Diaz rounded the Cape, to which he gave the name of Stormy, but which his more sanguine sovereign, John II. of Portugal, called the Cape of Good Hope. In 1498, Vasco da Gama, again sailing round the Cape, crossed the Eastern Ocean, and set foot on the Malabar coast at Calicut. Shortly after, Emmanuel, King of Portugal (1495-1521), assumed the title of ‘Lord of the navigation, conquest, and commerce of Æthiopia, Persia, Arabia, and India,’ and sent Almeyda to India with the title of viceroy, although he did not yet possess a foot of territory there. The Portuguese now pushed steadily up the western coast of India, defeated the princes who opposed them, and began to monopolise the trade. In 1505, the first Portuguese ships appeared at Antwerp, offering eastern wares at a cheaper rate than they could be got at Bruges, the market for the goods which came overland from Venice. This advance seriously threatened the Venetian trade through Egypt, then chiefly in the hands of Arabian and Moorish merchants. Accordingly, in 1509, the Sultan of Cairo, in answer to an appeal from some of the petty princes of the Malabar coast, despatched an expedition from Suez against the Portuguese, which the Venetians, conscious that their interests were involved, assisted. But in February 1509, three months before the battle of Agnadello, the expedition was defeated by Almeyda in the harbour of Diu. His successor Albuquerque fixed the centre of the Portuguese rule at Goa, and occupied Ormuz, an important port on the Persian Gulf. Henceforth the advance of the Portuguese was unchecked. By the close of the sixteenth century not only did they control the commerce of the coasts of Africa, Arabia, and the western coast of India, but they had planted themselves at Ceylon and in Bengal, had opened up a trade with China and Japan, and, above all, had occupied the true ‘Spice Islands’ which cluster round Borneo and Celebes (1546). Thus the same spring witnessed the fall of the Venetian military power in the battle of Agnadello, and the destruction of their trade with the East. The caravans no longer came to Cairo. The eastern goods were shipped round the Cape. The mediæval trade-routes were revolutionised, and the carrying trade passed from the Venetians to the Portuguese, shortly to be followed by the Dutch and English, while Antwerp took the place of Bruges as the ‘entrepôt’ in the North. Finally, the conquest of Egypt by Selim I. (1516) destroyed what remained of the Egyptian trade. This loss of commerce prevented Venice from recovering from her financial straits, and was the chief cause of her decline.